Table 1.
Metabolites that were altered significantly after GOLPH3L silencing
| Name | ID | VIP | Fold change | p-value |
|---|---|---|---|---|
| M348T450 | Adenosine monophosphate (AMP) | 5.35017309 | 0.343953619 | 1.85022E-09 |
| M489T438 | Cytidine 5′-diphosphocholine (CDP-choline) | 3.769023161 | 0.294683065 | 2.09147E-09 |
| M325T436 | Uridine 5′-monophosphate (UMP) | 2.859910755 | 0.36416908 | 1.85344E-08 |
| M136T425 | Adenine | 3.624555449 | 0.541578913 | 3.52988E-08 |
| M216T387 | sn-Glycerol 3-phosphoethanolamine | 3.817810077 | 0.662660731 | 1.64313E-07 |
| M113T160 | Uracil | 2.339930939 | 0.254999039 | 2.66289E-07 |
| M162T355_2 | L-carnitine | 2.259917766 | 0.687860774 | 5.55508E-07 |
| M244T235 | Cytidine | 1.320380286 | 0.343617832 | 6.16343E-07 |
| M664T430 | Nicotinamide adenine dinucleotide (NAD) | 5.426903613 | 0.531267518 | 6.8003E-07 |
| M204T426 | N-acetyl-D-glucosamine | 2.162566187 | 0.585855735 | 6.80877E-07 |
| M268T167 | Adenosine | 2.080090077 | 0.506337679 | 8.19558E-07 |
| M152T457 | 2-Hydroxyadenine | 1.192073219 | 0.418366736 | 1.00101E-06 |
| M364T457 | Guanosine 5′-monophosphate (GMP) | 2.20531908 | 0.381298814 | 1.34425E-06 |
| M598T474 | Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate) | 1.241389474 | 0.627904863 | 2.896E-06 |
| M810T418 | Acetyl coenzyme A (Acetyl-CoA) | 1.148074386 | 0.537400888 | 7.08625E-06 |
| M148T391 | L-glutamate | 3.853584751 | 0.737242788 | 8.94063E-06 |
| M584T438 | UDP-D-galactose | 1.033843982 | 0.641425356 | 9.98778E-06 |
| M137T166 | Hypoxanthine | 6.446185931 | 0.11746834 | 1.93784E-05 |
| M428T452_2 | Adenosine 5′-diphosphate (ADP) | 7.163025043 | 0.57751916 | 2.09404E-05 |
| M447T442 | CDP-ethanolamine | 1.026217107 | 0.611693587 | 2.16949E-05 |
| M291T464 | Argininosuccinic acid | 1.026399168 | 1.525518377 | 2.31077E-05 |
| M188T257 | DL-indole-3-lactic acid | 1.240956561 | 0.489217809 | 2.34219E-05 |
| M102T391 | 1-Aminocyclopropanecarboxylic acid | 1.410081315 | 0.756256635 | 2.38876E-05 |
| M246T242 | 2-Methylbutyroylcarnitine | 7.369334193 | 0.509326233 | 3.52739E-05 |
| M106T299 | Diethanolamine | 1.53304285 | 14.44114449 | 3.92078E-05 |
| M245T409 | Pro-Glu | 1.083816026 | 0.642279716 | 4.4156E-05 |
| M316T193 | Decanoyl-L-carnitine | 1.705457563 | 0.620089802 | 8.50963E-05 |
| M204T303 | Acetylcarnitine | 10.77036712 | 0.725339373 | 0.000102368 |
| M422T466 | Uridine 5′-diphosphate (UDP) | 1.109528766 | 0.668781099 | 0.000142935 |
| M400T159_2 | L-palmitoylcarnitine | 8.34588634 | 0.644174553 | 0.000177908 |
| M147T369 | L-pyroglutamic acid | 1.765274591 | 1.542951135 | 0.000179981 |
| M233T395 | Gamma-glutamylcysteine | 1.388401872 | 0.540837694 | 0.000320962 |
| M112T236 | Cytosine | 1.593691839 | 0.555964705 | 0.000415561 |
| M542T430 | ADP-ribose | 1.028412857 | 0.622601002 | 0.00064559 |
| M308T428 | Glutathione | 4.266509616 | 0.504989177 | 0.000716522 |
| M123T61 | Nicotinamide | 1.851347574 | 0.566997397 | 0.000943254 |
| M156T441 | L-histidine | 1.2602915 | 1.504208252 | 0.00100569 |
| M170T397 | 3-Methyl-L-histidine | 2.097791259 | 7.382253419 | 0.001046756 |
| M120T256 | Tyramine | 1.693843786 | 0.657319643 | 0.001442055 |
| M166T256 | L-phenylalanine | 1.120111864 | 0.675428936 | 0.002216965 |
| M146T374_2 | (3-Carboxypropyl) trimethylammonium cation | 3.995126207 | 0.750604189 | 0.002386475 |
| M132T263 | L-leucine | 1.432367955 | 0.424002729 | 0.002807843 |
| M179T427 | Cys-Gly | 1.127437605 | 0.643923687 | 0.006537627 |
| M258T457 | Glycerophosphocholine | 1.162325024 | 0.70923693 | 0.018142168 |
| M508T581 | Adenosine 5′-triphosphate (ATP) | 1.252149198 | 0.44136226 | 0.018216171 |
| M391T33 | Dioctyl phthalate | 5.057833924 | 0.806525311 | 0.019249997 |
| M613T491 | Glutathione disulfide | 2.467281297 | 0.722876989 | 0.059115948 |
| M468T200 | 1-Myristoyl-sn-glycero-3-phosphocholine | 1.668722344 | 2.054758707 | 0.059687763 |
| M118T462 | Betaine | 2.078707794 | 1.308639016 | 0.05975974 |
| M184T566 | Phosphorylcholine | 1.969089209 | 0.217723196 | 0.060512883 |
| M496T166 | 1-Palmitoyl-sn-glycero-3-phosphocholine | 3.467532932 | 1.405433036 | 0.060816012 |
| M203T505 | NG,NG-dimethyl-L-arginine (ADMA) | 1.02231111 | 0.612169445 | 0.079805836 |
| M130T542 | D-pipecolinic acid | 1.22345702 | 0.462637578 | 0.081203784 |
| M279T33 | Phthalic acid mono-2-ethylhexyl ester | 2.038184914 | 0.869293803 | 0.088733314 |
| M341T395 | maltose | 2.111953392 | 0.028561128 | 3.10543E-17 |
| M347T439 | Inosine 5′-monophosphate (IMP) | 3.625592991 | 0.301881382 | 6.71817E-16 |
| M322T450 | Cytidine 5′-monophosphate (CMP) | 1.192275542 | 0.62674391 | 2.23826E-14 |
| M662T429 | Nicotinamide adenine dinucleotide (NAD) | 5.135975169 | 0.567384075 | 4.63725E-13 |
| M547T437 | Cytidine 5′-diphosphocholine (CDP-choline) | 1.791062321 | 0.406528182 | 1.40724E-12 |
| M362T455 | Guanosine 5′-monophosphate (GMP) | 3.653583959 | 0.407242856 | 4.41861E-12 |
| M540T428 | Cyclic adenosine diphosphate ribose | 4.068411598 | 0.566724985 | 6.8843E-12 |
| M606T424 | UDP-N-acetylglucosamine | 18.47592875 | 0.611830043 | 7.85683E-12 |
| M323T434 | Uridine 5′-monophosphate (UMP) | 7.171175055 | 0.404982084 | 1.33639E-11 |
| M346T422 | Adenosine monophosphate (AMP) | 14.34548448 | 0.318588959 | 2.04199E-11 |
| M203T254 | L-tryptophan | 2.120508327 | 0.500782842 | 3.29102E-11 |
| M214T388 | sn-Glycerol 3-phosphoethanolamine | 9.759185833 | 0.725105379 | 3.90018E-11 |
| M242T234 | Cytidine | 1.768227149 | 0.351697024 | 1.48152E-10 |
| M445T440 | CDP-ethanolamine | 2.832548838 | 0.60943293 | 2.32647E-10 |
| M808T416 | Acetyl coenzyme A (acetyl-CoA) | 1.321582442 | 0.559526257 | 3.85093E-10 |
| M742T485 | Nicotinamide adenine dinucleotide phosphate (NADP) | 1.711544078 | 0.624512533 | 8.56497E-10 |
| M130T260 | L-Isoleucine | 3.729655739 | 0.588743745 | 1.07604E-09 |
| M613T434 | Cytidine monophosphate N-acetylneuraminic acid | 3.365736279 | 0.515824367 | 1.14679E-09 |
| M171T383 | Glycerol 3-phosphate | 3.123463887 | 0.690487464 | 1.17292E-09 |
| M147T385 | (S)-2-Hydroxyglutarate | 2.209506147 | 0.672217978 | 1.29056E-09 |
| M167T451 | Phosphoenolpyruvate | 3.418641375 | 1.879691109 | 1.38673E-09 |
| M174T387_2 | N-Acetyl-L-aspartic acid | 5.248401418 | 0.659295634 | 2.85219E-09 |
| M258T410 | D-Glucosamine 1-phosphate (glucosamine-1P) | 1.215448728 | 0.595730278 | 2.98007E-09 |
| M135T165 | Hypoxanthine | 2.83515564 | 0.155797031 | 3.3521E-09 |
| M565T436 | Uridine diphosphate glucose (UDP-D-glucose) | 4.94082239 | 0.593931258 | 5.65669E-09 |
| M239T387 | D-Mannose | 1.267493145 | 0.837341404 | 1.65544E-08 |
| M131T253 | Ethylmalonic acid | 1.942789906 | 0.670553701 | 2.25702E-08 |
| M182T474 | Phosphorylcholine | 1.592146407 | 0.776441511 | 5.19225E-08 |
| M426T481 | Adenosine 5′-diphosphate (ADP) | 2.142482016 | 0.786728943 | 6.27755E-08 |
| M403T463 | Uridine 5′-diphosphate (UDP) | 6.023335277 | 0.590303313 | 6.92096E-08 |
| M164T253 | L-phenylalanine | 2.745272587 | 0.649759377 | 1.09694E-07 |
| M128T370_1 | L-pyroglutamic acid | 1.084478181 | 1.326574096 | 1.35422E-07 |
| M259T448 | Alpha-D-glucose 1-phosphate | 1.955748269 | 1.727049692 | 6.43531E-07 |
| M303T435 | N-acetylaspartylglutamate (NAAG) | 1.092531363 | 0.622574707 | 1.04037E-06 |
| M145T372 | L-glutamine | 4.84006701 | 1.691397723 | 1.33369E-06 |
| M117T380_2 | Succinate | 3.22018177 | 0.745112292 | 1.33821E-06 |
| M146T390_2 | L-glutamate | 6.383368133 | 0.805813766 | 1.34212E-06 |
| M111T83 | Uracil | 4.093084571 | 0.338717051 | 1.98724E-06 |
| M255T38 | Palmitic acid | 15.91857778 | 1.482478443 | 2.63587E-06 |
| M462T486 | Adenylsuccinic acid | 1.400896234 | 0.601445092 | 3.04252E-06 |
| M179T387_2 | Myo-Inositol | 1.869509045 | 0.876085103 | 3.53295E-06 |
| M588T446 | GDP-L-fucose | 1.036473053 | 0.727980689 | 3.8859E-06 |
| M458T140 | L-palmitoylcarnitine | 1.71058671 | 0.69922387 | 3.95794E-06 |
| M296T70 | S-methyl-5′-thioadenosine | 2.695515248 | 0.562035793 | 5.0904E-06 |
| M114T308 | L-Proline | 1.492638552 | 0.844853133 | 6.29786E-06 |
| M130T386 | N-acetyl-L-alanine | 1.284618775 | 0.714233544 | 7.07193E-06 |
| M611T488 | Glutathione disulfide | 6.326051929 | 0.673543892 | 2.60415E-05 |
| M89T221_2 | DL-lactate | 6.180555782 | 0.771109869 | 3.15076E-05 |
| M506T481 | Adenosine 5′-triphosphate (ATP) | 6.265508138 | 0.776594367 | 7.93354E-05 |
| M133T396 | L-malic acid | 3.710482706 | 0.870781902 | 0.00015885 |
| M306T394 | Glutathione | 6.846802373 | 0.645572726 | 0.000202429 |
| M452T199 | 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 2.364541907 | 1.17565739 | 0.000288876 |
| M281T38 | Oleic acid | 10.56865128 | 1.261282292 | 0.000386302 |
| M337T38 | Erucic acid | 1.462001645 | 0.804834608 | 0.000563427 |
| M483T490 | Uridine 5′-triphosphate (UTP) | 2.985361942 | 0.791767071 | 0.000765923 |
| M673T189 | 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate | 1.958401653 | 1.956770427 | 0.001001254 |
| M253T38 | Cis-9-palmitoleic acid | 3.035713741 | 1.176091575 | 0.004203955 |
| M227T150 | Myristic acid | 1.009572648 | 1.48607569 | 0.004811555 |
| M197T38 | 3-Hydroxydodecanoic acid | 2.666768268 | 0.71831232 | 0.006944812 |
| M333T125 | Penicillin G | 1.82556849 | 0.584544716 | 0.009905013 |
| M273T34 | Salicylamide | 1.383050648 | 0.362734521 | 0.009978679 |
| M579T469 | Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate) | 3.315658544 | 0.86375998 | 0.010231094 |
| M141T353 | 2-Oxoadipic acid | 11.40052894 | 0.912787301 | 0.015048419 |
| M130T344 | Creatine | 1.009533641 | 0.795141329 | 0.017407461 |
| M154T411 | Urocanic acid | 1.176119208 | 1.475399848 | 0.020677476 |
| M173T432 | Cis-Aconitate | 1.169850112 | 0.768659387 | 0.021442597 |
| M219T2 | 4-Nonylphenol | 2.042585348 | 1.263228143 | 0.043438355 |
| M134T153 | Adenine | 1.249418803 | 0.62240901 | 0.043527968 |
| M269T136 | Heptadecanoic acid | 1.030910387 | 0.689149164 | 0.05747134 |
| M131T375 | L-asparagine | 1.700684605 | 1.62285133 | 0.061339629 |
| M191T497 | Citrate | 2.212863083 | 0.850809508 | 0.067218448 |
| M181T296 | D-threitol | 1.061736173 | 0.563835355 | 0.079699611 |
Legend: Untargeted metabolomics sequencing was used to reveal metabolites that were altered significantly after GOLPH3L silencing, and those with p-values< 0.05 are indicated