Table 4.
KEGG pathways involved in GOLPH3L-silenced breast cancer cells
| Database | ID | P-Value | Corrected P-Value | Genes |
|---|---|---|---|---|
| KEGG PATHWAY | hsa04933 | 5.42713E-07 | 7.32662E-05 | CCL2;PIK3CB;SERPINE1;KRAS;TGFB2 |
| KEGG PATHWAY | hsa05142 | 2.07617E-05 | 0.001401414 | CCL2;PIK3CB;TGFB2;SERPINE1 |
| KEGG PATHWAY | hsa05210 | 0.000126423 | 0.003878901 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa05212 | 0.000151007 | 0.003878901 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa05211 | 0.000157602 | 0.003878901 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04062 | 0.00018996 | 0.003878901 | CCL2;PIK3CB;KRAS;CCR2 |
| KEGG PATHWAY | hsa05220 | 0.000201128 | 0.003878901 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04211 | 0.000412618 | 0.006962933 | PIK3CB;KRAS;ADIPOQ |
| KEGG PATHWAY | hsa05160 | 0.001101508 | 0.01518735 | PIK3CB;KRAS;CLDN1 |
| KEGG PATHWAY | hsa04068 | 0.001124989 | 0.01518735 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04530 | 0.001247139 | 0.015305797 | VAPA;KRAS;CLDN1 |
| KEGG PATHWAY | hsa05161 | 0.001431726 | 0.016106915 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04960 | 0.001705229 | 0.017708152 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04360 | 0.002413822 | 0.022159731 | EFNB2;PIK3CB;KRAS |
| KEGG PATHWAY | hsa04930 | 0.002525744 | 0.022159731 | PIK3CB;ADIPOQ |
| KEGG PATHWAY | hsa05144 | 0.002626339 | 0.022159731 | CCL2;TGFB2 |
| KEGG PATHWAY | hsa05213 | 0.00293929 | 0.023341421 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05223 | 0.003382408 | 0.024852551 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05221 | 0.003497766 | 0.024852551 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05205 | 0.003682986 | 0.024860155 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04370 | 0.003977354 | 0.025568702 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04213 | 0.004355952 | 0.026010475 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05214 | 0.004485724 | 0.026010475 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05230 | 0.004750595 | 0.026010475 | PIK3CB;SERPINE1 |
| KEGG PATHWAY | hsa04664 | 0.004885683 | 0.026010475 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05218 | 0.005301493 | 0.026010475 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04917 | 0.005443594 | 0.026010475 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa03320 | 0.005443594 | 0.026010475 | OLR1;ADIPOQ |
| KEGG PATHWAY | hsa04662 | 0.005587435 | 0.026010475 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa01521 | 0.006800173 | 0.030390563 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05166 | 0.006978574 | 0.030390563 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04060 | 0.007424504 | 0.031322125 | CCL2;TGFB2;CCR2 |
| KEGG PATHWAY | hsa04012 | 0.007950284 | 0.032246156 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05215 | 0.008121254 | 0.032246156 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05323 | 0.008468143 | 0.032662838 | CCL2;TGFB2 |
| KEGG PATHWAY | hsa01522 | 0.009548044 | 0.034763406 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04914 | 0.009733696 | 0.034763406 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04915 | 0.009920954 | 0.034763406 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05146 | 0.010109813 | 0.034763406 | PIK3CB;TGFB2 |
| KEGG PATHWAY | hsa05231 | 0.010300268 | 0.034763406 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04066 | 0.010685948 | 0.035185438 | PIK3CB;SERPINE1 |
| KEGG PATHWAY | hsa04660 | 0.011077952 | 0.035607703 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04668 | 0.012085376 | 0.037712623 | CCL2;PIK3CB |
| KEGG PATHWAY | hsa04725 | 0.012291521 | 0.037712623 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04919 | 0.013777442 | 0.039775364 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04670 | 0.013777442 | 0.039775364 | PIK3CB;CLDN1 |
| KEGG PATHWAY | hsa05145 | 0.013995787 | 0.039775364 | PIK3CB;TGFB2 |
| KEGG PATHWAY | hsa04722 | 0.014215636 | 0.039775364 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04071 | 0.014436984 | 0.039775364 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04152 | 0.015337266 | 0.041410618 | PIK3CB;ADIPOQ |
| KEGG PATHWAY | hsa04380 | 0.016969364 | 0.044918905 | PIK3CB;TGFB2 |
| KEGG PATHWAY | hsa04650 | 0.01769056 | 0.045927416 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04910 | 0.018672129 | 0.047302645 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04210 | 0.018921058 | 0.047302645 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04550 | 0.019423126 | 0.047674946 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04072 | 0.019930779 | 0.048047414 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05200 | 0.021609077 | 0.05050568 | PIK3CB;TGFB2;KRAS |
| KEGG PATHWAY | hsa04932 | 0.021751022 | 0.05050568 | PIK3CB;ADIPOQ |
| KEGG PATHWAY | hsa04390 | 0.022551551 | 0.05050568 | TGFB2;SERPINE1 |
| KEGG PATHWAY | hsa04150 | 0.022551551 | 0.05050568 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04145 | 0.022821085 | 0.05050568 | VAMP3;OLR1 |
| KEGG PATHWAY | hsa04921 | 0.023637696 | 0.051469176 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa05164 | 0.028783631 | 0.06167921 | CCL2;PIK3CB |
| KEGG PATHWAY | hsa05168 | 0.031818708 | 0.067117587 | CCL2;TAF9B |
| KEGG PATHWAY | hsa04977 | 0.036402182 | 0.075604532 | LMBRD1 |
| KEGG PATHWAY | hsa05169 | 0.037582935 | 0.076394178 | POLR3G;PIK3CB |
| KEGG PATHWAY | hsa05203 | 0.037914147 | 0.076394178 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04015 | 0.039924992 | 0.079262851 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04810 | 0.041287714 | 0.08078031 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa04320 | 0.042104357 | 0.081201261 | KRAS |
| KEGG PATHWAY | hsa05216 | 0.04352471 | 0.082758252 | KRAS |
| KEGG PATHWAY | hsa04014 | 0.045835719 | 0.085941973 | PIK3CB;KRAS |
| KEGG PATHWAY | hsa00640 | 0.047773358 | 0.0871541 | ECHDC1 |
| KEGG PATHWAY | hsa03020 | 0.047773358 | 0.0871541 | POLR3G |
Legends: KEGG pathways of different metabolites that were altered significantly after GOLPH3L silencing, p-values< 0.05