Fig. 3.
Aβ1-42-induced hippocampal neurones exhibited an increase in apoptosis and a decrease in the membrane transport of GluA1. Hippocampal neurones were treated with Aβ1-42 oligomer (10 μmol/L) for 24 h. Normal hippocampal neurones were served as control. a The apoptosis of hippocampal neurones was examined by flow cytometry. b WB was performed to detect the expression of caspase-1 and GluA1 in the hippocampal neurones. c ELISA was performed to assess the levels of IL-1β in the hippocampal neurones. S: surface; I: intracellular. (Student’s t test; *P < 0.05, **P < 0.01 vs. Ctrl group.)