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. 2021 Jan 28;9:7. doi: 10.1186/s40170-021-00243-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effectiveness of RNF115 expression on proliferation and apoptosis in LUAD cells. a–e Comparison of RNF115 expression, cellular proliferation, and apoptosis between H358 or H1975 cells transfected with shRNF115 (1# and 2#) and control shRNA (NC). a Expression of RNF115 protein by western blotting with the loading control as GAPDH. b, c Measurement of cell proliferation by CCK-8 assay (b) and Click-iT EdU Cell Proliferation Assay (c). d The ratio of apoptotic cells. ***P < 0.001 vs NC. e Expression of PCNA and Cleaved caspase-3 by western blotting. f–i Comparison of RNF115 expression, cellular proliferation, and apoptosis between H1299 cells transfected with oeRNF115 and Vector control. f Expression of RNF115 protein by western blotting with the loading control as GAPDH. g, h Measurement of cell proliferation by CCK-8 assay (g) and Click-iT EdU Cell Proliferation Assay (h). i The ratio of apoptotic cells. **P < 0.01 and ***P < 0.001 vs Vector