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. 2021 Jan 28;9:7. doi: 10.1186/s40170-021-00243-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of RNF115 knockdown in cellular metabolism of LUAD. a Correlation between the expression of RNF115 and glycolytic activity (upper panel) or β-catenin pathway (lower panel) by GSEA based on TCGA database. b–e Comparison of energy metabolism and related protein expressions between H358 or H1975 cells transfected with shRNF115 (1# and 2#) and control shRNA (NC). b Extracellular acidification rates for glycolysis. c Oxygen consumption rates for mitochondrial respiration. d Expressions of HK-2 and LDHA proteins in cytosol by western blotting with the loading control as GAPDH. e Expression of β-catenin in nucleus by western blotting with the loading control as H3. *P < 0.05, **P < 0.01, and ***P < 0.001 vs NC