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. Author manuscript; available in PMC: 2021 Jan 28.
Published in final edited form as: Mol Psychiatry. 2020 Feb 7;25(10):2220–2236. doi: 10.1038/s41380-020-0667-y

Figure 2. A working model for NCOR functions in the brain.

Figure 2.

The NCOR complex is recruited to the genome either by DNA-binding nuclear receptors (NRs), other transcription factors (TFs), or MECP2 that recognizes methylated DNA regions. The NCOR complex is sensitive to hormones, metabolites, xenobiotics, and chemicals that can function as NR ligands or HDAC inhibitors. The NCOR complex regulates the transcription of multiple genes involved in neurotransmission and synaptic plasticity.