. Author manuscript; available in PMC: 2021 Jan 28.

Published in final edited form as: Mol Psychiatry. 2020 Feb 7;25(10):2220–2236. doi: 10.1038/s41380-020-0667-y

Table 1:

Genetic mouse models of the NCOR complex and related genes.

Brain region/cell type targeted	Target gene	Mouse model	Life span	Body weight	Brain weight	Behavioral phenotype									Ref.
Brain region/cell type targeted	Target gene	Mouse model	Life span	Body weight	Brain weight	Breath regularity	Motility	Hindlimb clasping	Motor coord.	Anxiety	Social Interact.	Learning/memory	E/I balance	Hippo LTP	Ref.
Whole body	Mecp2	Mecp2 ^−/− or Mecp2 ^-/y (Mecp2-KO)	↓	↓/←	↓	↓	↓	↑	↓	↓	↑/↓	↓	CA1↑ CA3↑ Bs↑Ctx↓	–	[44–51]
		Mecp2^R306C/y	↓	–	↓	–	↓	↑	↓	–	–	–	–	–	[29]
		Mecp2^T308A/y	–	←	↓	–	–	↑	↓	–	–	–	–	–	[28]
	Ncor1/2	Ncor1^Y478A/Y478A; Ncor2^Y470A/Y470A (NS-DADm)	← *	←	←	←	↑	←	↑	↓	↓	↓	–	–	[19]
	Shank3	Shank3^−/−	–	←	–	–	←/↓	–	↓/←	←/↑	↓	↓/←	CA1↑/←	↓	[132–136]
	Mef2c	Mef2c^+/−	↓	↓	–	–	←	↑	–	↑	↓	↓	Hippo↑	–	[165]
	Foxp2	Foxp2^−/−	↓	↓	–	–	–	–	↓	–	↓	–	–	–	[152, 153]
	Foxp2	Foxp2^+/−	←	←/↓	–	–	–	-	←	–	↓	←	–	–	[152, 153]
GABA neuron	Mecp2	Vgat-Cre; Mecp2^loxP/y	↓	↓	–	↓	↓	↑	↓	←	↑	↓	Ctx PN↑ Str GN↑	↓	[52]
	Ncor1/2	Vgat-Cre; Ncor1^loxP/loxP; Ncor2^loxP/loxP (NS-V)	–	–	–	–	←	–	–	←	↓	↓	Hypo↑ CA3↓	↓	[19]
	Shank3	Vgat-Cre;Shank3^loxP/loxP	–	–	–	–	↓	–	–	↑	←/↓	–	DL Str Neuron↓	–	[140]
Forebrain neuron	Mecp2	Camk2-Cre;Mecp2^loxP/loxP	↓	↑	↓	↓	↓/←	←	↓	↑	↑	↓	–	–	[53, 54]
	Hdac3	Camk2-Cre;Hdac3^loxP/loxP	–	–	–	–	↑	↑	↓	–	↓	↓	–	–	[43]
	Mef2c	Camk2-Cre;Mef2c^loxP/loxP	–	–	–	–	↑	↑	↓	←	←	←	←	←	[169]
Neural progenitor	Mef2c	Nestin-Cre;Mef2c^loxP/-	↓	↓	↓	–	←	↑	-	↑	–	↓	Ctx↓	–	[166]
Neural progenitor	Mef2c	hGFAP-Cre;Mef2cloxP^/-	–	↓	←	–	←	↑	↓	←	–	↓	–	–	[167]
Ctx and Hippo excitatory neuron	Mef2c	Emx1-Cre;Mef2c^loxP/loxP	–	–	–	–	↑	–	←	–	↓	↓	Ctx↓	–	[168]
Ctx and Hippo excitatory neuron	Foxp2	Nex-Cre;Foxp2^lop/loxP	–	←	–	–	–	–	–	←	↓	–	–	–	[154]
Hippo	Hdac3	AAV-Cre into CA1 of Hdac3^loxP/loxP	–	–	–	–	–	–	–	–	–	↑	–	–	[23]
	Hdac3	AAV-Cre into CA3 of Hdac3^loxP/loxP	–	–	–	–	–	–	–	–	–	←	–	–	[19]
	Mecp2	AAV-shRNA at adult dorsal hippocampus	–	–	–	–	←	–	–	←	–	↓	–	–	[55]
Hypo	Hdac3	AAV-Cre into Hdac3^loxP/loxP	–	–	–	–	–	–	–	–	–	↓	–	–	[19]
Hypo	Mecp2	Sim1-Cre; Mecp2^loxP/y	←	↑	–	–	←	↑	←	↑	←	←	–	–	[56]

^←,

no change

^↓,

decrease

^↑,

increase

^–,

not determined; Bs, brainstem; Ctx, Cortex; Hippo, hippocampus; Hypo, hypothalamus; Str, striatum; PN, pyramidal neuron; DL, dorsolateral.

survive for at least 1 year.