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Plasma (A) and brain (B) concentrations of valsartan following oral administration (0.2 mg/kg) to WT (closed circles) and APP/PS1 mice (open squares). ^ Brain concentrations of valsartan were only detectable in one WT mouse at 1 h and were undetectable at later time points. # Brain concentrations of valsartan were only detectable in two APP/PS1 mice at 2 h and were undetectable at later time points. Data are presented as mean ± SD (n=3).
