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. Author manuscript; available in PMC: 2021 May 4.

Published in final edited form as: Mol Pharm. 2020 Apr 8;17(5):1527–1537. doi: 10.1021/acs.molpharmaceut.9b01227

Figure 5. — The appearance of (A) ¹⁴C-caffeine, (B) ³H-diazepam, (C) valsartan, (D) ³H-digoxin, and (E) ¹⁴C-mannitol in the receptor chamber following transport across the jejunum from WT (closed circles) and APP/PS1 mice (open squares) after application of a dose of 0.5 μCi (radioactive compounds) or 20 μg/mL (valsartan). ^ Concentrations of valsartan were only detectable in 2 replicates. Data are presented as mean ± SD (n = 6-9).

Figure 5. — The appearance of (A) ¹⁴C-caffeine, (B) ³H-diazepam, (C) valsartan, (D) ³H-digoxin, and (E) ¹⁴C-mannitol in the receptor chamber following transport across the jejunum from WT (closed circles) and APP/PS1 mice (open squares) after application of a dose of 0.5 μCi (radioactive compounds) or 20 μg/mL (valsartan). ^ Concentrations of valsartan were only detectable in 2 replicates. Data are presented as mean ± SD (n = 6-9).