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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Mol Pharm. 2020 Apr 8;17(5):1527–1537. doi: 10.1021/acs.molpharmaceut.9b01227

Table 1.

The AUCplasma, AUCbrain and z values of probe compounds following oral administration to WT and APP/PS1 mice. Data are presented as mean ± SD (n=3).

Compound AUCplasma (ng·h/mL) AUCbrain (ng·h/g)
WT APP/PS1 z value WT APP/PS1 z value
Caffeine 10380 ± 738 11289 ± 681 0.90 21520 ± 224 22178 ± 356 1.56
Diazepam 356.6 ± 35.6 343.3 ± 29.2 0.29 119.5 ± 5.5 117.7 ± 18.2 0.10
Valsartan 1960 ± 231 1388 ± 105 2.26* NA NA
Digoxin 199.4 ± 12.7 154.1 ± 16.8 2.14* NA NA

NA: AUC value was not able to be calculated due to the detection limit of the brain assay.

*

z > 1.96 indicates a significant difference in AUCplasma or AUCbrain between WT and APP/PS1 mice.