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. Author manuscript; available in PMC: 2021 May 4.
Published in final edited form as: Mol Pharm. 2020 Apr 8;17(5):1527–1537. doi: 10.1021/acs.molpharmaceut.9b01227

Table 2.

Apparent permeability coefficients (Papp) and percentage (%) of the initial amount of compounds absorbed after 120 min through jejunal tissue from WT and APP/PS1 mice. Data are presented as mean ± SD (n=4-9).

Compound Papp (×10−6 cm/s) % of initial amount at 2 h
WT APP/PS1 WT APP/PS1
14C-Caffeine 31.4 ± 10.1 27.2 ± 13.8 0.40 ± 0.09 0.46 ± 0.14
3H-Diazepam 29.1 ± 9.7 34.1 ± 9.2 0.42 ± 0.12 0.52 ± 0.12
Valsartan 55.8 ± 16.7 NA 0.81 ± 0.19 0.43 ± 0.23*
3H-Digoxin 64.2 ± 39.4 14.5 ± 11.0* 0.85 ± 0.30 0.22 ± 0.11*
14C-Mannitol 10.7 ± 3.7 6.0 ± 3.4* 0.17 ± 0.05 0.12 ± 0.04*

NA: Steady state was not reached and the Papp value was not able to be calculated.

*

p < 0.05 indicates a statistically significant difference between WT and APP/PS1 mice.