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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Am J Transplant. 2019 Nov 18;20(4):924–930. doi: 10.1111/ajt.15660

Figure 1. Eosinophil mediated suppression of T cell alloimmune responses.

Figure 1.

(A) ISHLT A rejection grade and KI67 (expressed as %) in CD8+ and CD4+ graft resident T cells seven days after engraftment of Balb/c lungs to C57BL/6 recipients with eosinophil depletion accomplished by IL-5 neutralization. All grafts were treated with co-stimulatory blockade immunosuppression affected by CTLA-4 Ig and anti-CD40L (clone MR1). (B) ISHLT A rejection grade and T cell proliferation (expressed as total number of KI67+ T cells) in Balb/c lungs engrafted to iPHIL mice on a C57BL/6 background with eosinophil depletion accomplished by diphtheria toxin administration. (reproduced from74,75 *** p<.001, **p<.01, *p<.05)