Table 2.
Demographic and biological characteristics of 104 patients.
| Mean ± standard deviation | Minimum | Maximum | |
|---|---|---|---|
| Age, years | 63.0 ± 14.4 | 25 | 99 |
| Weight, kg | 79 ± 16 | 40 | 150 |
| Height, cm | 169 ± 11 | 146 | 192 |
| BMI, kg/m2 | 27.3 ± 5.0 | 17.8 | 51.9 |
| Sex, (female) % | 32 | NA | NA |
| Patient in intensive care, % | 23 | NA | NA |
| MDRD, mL/min/1.73 m2 | 86.0 ± 33.6 | 5 | 194 |
| Creatinine, μmol/L | 98 ± 82 | 34 | 808 |
| Albumin, g/L | 29.0 ± 6.9 | 12 | 63 |
| HT, %. | 35.0 ± 6.5 | 18 | 49 |
| Platelet, 109 L | 313 ± 134 | 52 | 753 |
| White blood cells, 109 L | 7.5 ± 4.7 | 2 | 32.4 |
| C-reactive protein (CRP), mg/L | 86 ± 98 | 2 | 469 |
| ALAT, U/L | 69 ± 74 | 11 | 486 |
| ASAT, U/L | 63 ± 49 | 13 | 252 |
| Dose HCQ, mg/day | 563 ± 99 | 200 | 800 |
| Observation duration, days | 5.3 ± 2.3 | 1 | 12 |
| Blood concentration | |||
| HCQ, ng/mL | 586 ± 457 | 50 | 2792 |
| Plasma concentration | |||
| HCQ, ng/mL | 193 ± 152 | 12 | 795 |
| HCQBlood/HCQPlasma | 4.0 ± 2.3 | 1 | 15 |
ALAT: alanine aminotransferase; ASAT: aspartate aminotransferase; BMI: body mass index; HCQ: hydroxychloroquine; HT: hematocrit; NA: non-applicable; MDRD: modification of diet in renal disease equation.
All data were collected at the time of HCQ sampling.