Figure 1. LPS induced PMT in a swine model of LPS-induced AKI.

A. Representative pictures of PDGRβ and α-SMA staining performed in swine renal sections of healthy and endotoxemic pigs.Pericytes were double-stained for PDGFRβ (green) and α-SMA (red). In healthy pigs (T9 CTR), α-SMA immunostaining signal was detected only within vascular smooth-muscle cells (dotted white arrow) and PDGFRβ⁺/αSMA⁺ perivascular cells were barely detectable. In endotoxemic pigs (T9 LPS) the number of PDGFRβ⁺/αSMA⁺ cells significantly increased (white arrows), as shown by the colocalization of the two markers in the interstitiumand at glomerular level. Magnification 630X. B. Quantitative data (n = 5 for each group, P = 0.001). Results are expressed as median ± IQR of five independent pigs for each group. The statistical analysis was performed using the Mann-Whitney test. Modified from Figure 1 in Castellano et al. (2019) . License: (http://creativecommons.org/licenses/by/4.0/).