Skip to main content
. 2020 Jul 5;10(13):e3670. doi: 10.21769/BioProtoc.3670

Table 1. Conditions for tandem mass spectrometry analysis of lipid species.

Lipid class/subclass Shorthand Parent Ion Fragmentation* Collision Energy (V) Example Species Example Transition (m/z, Q1/Q3)
Sphingosine Sph [M+H]+ NL, 18.0 Da 8 Sph(d18:1) 300.3 282.3
Sphingosine-1-phosphate S1P [M+H]+ Sphingoid specific^ 11-16 S1P(d18:1) 380.2 264.3
Dihydroceramide dhCer [M+H]+ Sphingoid specific^ + H2O 31 dhCer(d18:1/24:0) 652.7 284.3
Ceramide Cer [M+H]+ Sphingoid specific^ 23-29 Cer(d18:1/20:0) 594.6 264.3
Monohexosylceramide HexCer [M+H]+ Sphingoid specific^ 33 HexCer(d18:1/24:0) 812.7 264.3
Dihexosylceramide Hex2Cer [M+H]+ Sphingoid specific^ 53 Hex2Cer(d18:1/24:1) 972.7 264.3
Trihexosylcermide Hex3Cer [M+H]+ PI, m/z 264.3 57 Hex3Cer(d18:1/20:0) 1080.7 264.3
GM3 ganglioside GM3 [M+H]+ Sphingoid specific^ 57 GM3(d18:1/24:1) 1263.8 264.3
GM1 ganglioside GM1 [M+2H]2+ PI, m/z 366.2 9 GM1(d18:1/16:0) 760.1 366.2
Sulfatide Sulfatide [M+H]+ PI, m/z 264.3 56 Sulfatide(d18:1/24:0) 892.8 264.3
Ceramide-1-phosphate Cer1P [M+H]+ PI, m/z 264.3 29 Cer1P(d18:1/16:0) 618.4 264.3
Sphingomyelin SM [M+H]+ PI, m/z 184.1 25 SM(d34:1) 703.6 184.1
Phosphatidylcholine PC [M+H]+ PI, m/z 184.1 21 PC(34:2) 758.6 184.1
Alkylphosphatidylcholine PC(O) [M+H]+ PI, m/z 184.1 21 PC(O-38:4) 796.6 184.1
Alkenylphosphatidylcholine PC(P) [M+H]+ PI, m/z 184.1 21 PC(P-38:6) 790.6 184.1
Lysophosphatidylcholine LPC [M+H]+ PI, m/z 184.1 21 LPC(16:0) 496.3 184.1
Lysoalkylphosphatidylcholine LPC(O) [M+H]+ PI, m/z 104.1 21 LPC(O-18:0) 510.4 104.1
Lysoalkenylphosphatidylcholine LPC(P) [M+H]+ PI, m/z 104.1 21 LPC(P-18:1) 506.3 104.1
Phosphatidylethanolamine

PE

[M+H]+ NL, 141.0 Da 17 PE(36:2) 744.6 603.6
Alkylphosphatidylethanolamine PE(O) [M+H]+ NL, 141.0 Da 17 PE(O-36:4) 726.5 585.5
Alkenylphosphatidylethanolamine PE(P) [M+H]+ Acyl specific 17 PE(P-16:0/20:4) 724.5 361.3
Lysophosphatidylethanolamine LPE [M+H]+ NL, 141.0 Da 17 LPE(20:4) 502.3 361.3
Lysoalkenylphosphatidylethanolamine LPE(P) [M+H]+ NL, 171.9 Da 19 LPE(P-16:0) 438.3 266.4
Phosphatidylinositol PI [M+NH4]+ NL, 277.0 Da 17 PI(32:1) 826.5 549.5
Lysophosphatidylinositol LPI [M+NH4]+ NL, 277.0 Da 17 LPI(20:4) 638.3 361.3
Phosphatidylserine  PS [M+H]+ NL, 185.0 Da 25 PS(38:4) 812.5 627.5
Phosphatidylglycerol PG [M+NH4]+ NL, 189.0 Da 21 PG(36:2) 792.6 603.6
Free cholesterol COH* [M+NH4]+ PI, m/z 369.3 23 COH 369.4 161.2
Cholesteryl ester

CE

[M+NH4]+ PI, m/z 369.3 10 CE(18:2) 666.6 369.3
Dehydrochoesteryl ester DE [M+NH4]+ PI, m/z 367.3 12 DE(18:1) 666.6 367.3
Acylcarnitines AC [M+H]+ PI, m/z 85.1 30 AC(16:0) 400.4 85.1
Diacylglycerol DG [M+NH4]+ NL, fatty acid 21 DG(16:0_18:2) 610.5 313.2
Triacylglycerol TG [M+NH4]+ NL, fatty acid 21 TG(54:3) [NL-18:1] 902.8 603.5
Alkyldiacylglycerol TG(O) [M+NH4]+ NL, fatty acid 21 TG(O-52:2) [NL-16:0] 862.8 589.5
Ubiquinone Ubiquinone [M+NH4]+ PI, m/z 197.0 17 Ubiquinone 880.7 197.0