Table 5.
CapOX | mFOLFOX6 | |||
---|---|---|---|---|
Hospital visits | Every 3 weeks | Every 2 weeks | ||
Port-catheter | Not require | Require | ||
Our study | XELOXA | MOSAIC | JOIN | |
Dose intensity | ||||
Oxaliplatin | 76.5% | 87.0% | >80.0% | 78.2% |
Capesitabine | 75.8% | 84.0% | – | – |
5-FU | – | – | 84.4% | 87.7% (bolus), 78.1% (infusion) |
Treatment completion | 82.9% | 69.0% | 74.7% | 67.0% |
DFS rate | 63.8% (five-year) | 66.1% (five-year) | 73.3% (five-year) | – |
OS rate | 71.0% (five-year) | 77.6% (five-year) | 78.5% (six-year) | – |
HFS (>grade 3) | 0% | 5.0% | – | – |
PSN (>grade 3) | 17.1% | 9.0% | 12.4% | 5.8% |
HFS, hand–foot syndrome; PSN, peripheral sensory neuropathy.