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. 2021 Jan 27;41(4):739–750. doi: 10.1523/JNEUROSCI.1050-20.2020

Figure 4.

Figure 4.

Effect of l-theanine on THC-induced abnormalities in spontaneous cortical gamma oscillations (30–80 Hz). A, Representative spectrogram of a 5 min recording during desynchronized state, characterized by small-amplitude fast oscillations (trace on the top). LFP power values between 59 and 61 Hz were excluded since they were reflecting the power line frequency. B, Average normalized power spectra representing LFP during the desynchronized state in prefrontal cortex of the four experimental groups. The THC-treated group displayed a decrease in total gamma oscillations (30–80 Hz) during the desynchronized state. l-Theanine prevented THC-induced abnormalities in prefrontal LFP gamma oscillations. C, Group summary comparing LFP power following adolescent treatments. The THC-induced reduction in the total power of gamma oscillations in the desynchronized state was fully prevented by pre-exposure to l-theanine (n = 20 recording sites from 6 vehicle rats; n = 17 recording sites from 3 THC rats; n = 23 recording sites from 4 thea + THC rats; n = 17 recording sites from 4 theanine rats; two-way ANCOVA, post hoc Fisher's LSD; *p < 0.05, ***p < 0.001).