Figure 7.

Cysteine substitution affects learning and memory performance. A, Learning performance of animals at 6 and 3 pairings accumulating pan-neuronally the indicated Tau variants (black bars) compared with driver and transgene heterozygotes (white and gray bars). The genotypes of all animals are indicated below each bar. Data are mean ± SEM. *p < 0.05, significant differences from both controls. The number of experimental replicates (n) is indicated within the bars. Expression of wt Tau caused impairment in learning in both conditions, whereas expression of C291A mutant caused impairment in learning only under limited training with 3 pairings. B, Memory performance of animals accumulating pan-neuronally the indicated Tau transgenes (black bar), compared with driver and transgene heterozygotes (white and gray bars). The genotypes of all animals are indicated below each bar. Data are mean ± SEM. *p < 0.05, significant differences from both controls. The number of experimental replicates (n) is indicated within the bars. Only expression of wt Tau caused impairment in LTM. C, Pan-neuronal expression of wt Tau (black bar) does not affect memory after massed training (ARM, p > 0.05), compared with driver and transgene heterozygotes (white and gray bars). The number of experimental replicates (n) is indicated within the bars. Data are mean ± SEM. Detailed statistics can be found in the text. Trs, Transgene.