Table 2.

Fibrotic Genes Involved in the Lung (IPF) and Hand (DD) From Our Review.

Fibrotic Pathway	Lung (IPF)	Hand (DD)
ECM remodeling and fibroblast regulation (cell-cell adhesion, apoptotic regulation, integrity and mechanotransduction)	ACTA-2, ACTG2, ATP1A2, BRSK2 (rs71469892), CARD10, CLPTM1L (rs4449583), DES, DPP9, DSP (rs72825054, rs2744373, rs2744371, rs17133512, rs145125286, rs2008756, rs2237105), DYM, EIF1AY, MCF2L (rs1278769), MDGA2 (rs7144383), MFSD2A, MGMT, MIR4457(rs4449583), MYH11, NLGN4Y, PIGA, RNPS1, RPS4Y1, RTEL1, SCN1A, SLFNL1, SLN, SPPL2C (rs17690703), SYNPO2, TAGLN, TP53 (rs12951053, rs12602273), TPM2, VDAC3	AEN, CARD11, DAD1, DDR2, EIF3E (rs611744), EPDR1 (rs16879765), FBXL7 (rs6897647), FBXO45 (rs7426655), ITGA11, KRT15, KRT19, MAFB (rs8124695), MMP14, MMP21/22B, SAV1, TIMP2 (rs4789939), TMEM170A
Immune system dysfunction	DDX3Y, HLA (rs3117116), HLA-DRB1*15, IL-10, IL-1alpha, IL-4, IL-6 (intron 4G), IL1A, IL1B (rs1143627, rs1143634, rs1143643, rs1799916), IL1RN (rs11677397, rs2637988, rs397211, rs408392), IL3, IL4, IL8 (s4073T> A, rs2227307T> G, rs2227306C > T, IL8_ht3), KDM5D, R131H (FcgRIIa), UTY	CCL18, CFHR1, CFHR3, DGAT1, HCG27\\HLA-C (rs3132506, rs3130473), HCG4P6, HLA-A, HLA-DR4, HLA-DRB1*01, HLA-DRB1*15, ISG20, PRKX (rs17335275), SIRPB1, TRGC2, TRGV9
Profibrotic mediators	ADAMTSL5, ALX4, CDKN1A (rs2395655, rs733590), CDKN2B, CNN1, FAM13A (rs2609260), FAM83D, FZD5, GBP4, HFE (C282Y, S65C, H63D), IFI44L, IFIT3, IGFBP5, IGFBP6, KAAG1, OAS-2, PCDH9, SLC1A2, SLC22A11, SLC39A8, SLC6A14, SLCO4C1, TF, TGF- β1, TNF-RII, TNF-α, TOLLIP(rs111521887, rs5743894, rs5743890), ZFY, ZNF385B	ADAM3A, FKBP1A, HSF1, LRRC33 (rs7426656), MAP4K5, NEDD4, RSPO2 (rs611744), SDK1, SERP2, SFRP4 (rs16879765), TAB2, TGFB1, TGFbRI-3’UTR, TGFbRII-3’UTR3, TGFbRII-e5, TGFbRIII-3’UTR, WNT2 (rs4730775), WNT4 (rs7524102), WNT5A, Wnt7B (rs8140558, rs6519955), X89654, ZBTB40, ZC3H12D, Zf9–3’, Zf9–3’2, Zf9-c, ZIC1, ZIM3, ZNF160, ZNF264

DD, Dupuytren disease; ECM, extracellular matrix; IPF, idiopathic pulmonary fibrosis.