#	Searches	Results
1	exp Fibrosis/ge [Genetics]	1551
2	exp Pulmonary Fibrosis/ge [Genetics]	1419
3	exp Endomyocardial Fibrosis/ge [Genetics]	80
4	exp Dupuytren Contracture/ge [Genetics]	166
5	(arthrofibroses or arthrofibrosis or fibroses or fibrosis).ti,ab,hw,kw.	547,154
6	Genetics/	704,070
7	Genomics/	104,087
8	exp Genetic Predisposition to Disease/	281,969
9	(gene or genes or genetic or genetics or genomic or genomics).ti,ab,hw,kw.	7,915,383
10	6 or 7 or 8 or 9	7,915,383
11	exp Joint Diseases/ge [Genetics]	16,780
12	exp Joints/	668,503
13	exp Shoulder Joint/ or exp Shoulder/	94,461
14	exp Hand/ or exp Hand Joints/	175,741
15	exp Knee/ or exp Knee Joint/	133,234
16	exp Heart Diseases/ge [Genetics]	47,024
17	(arthrofibroses or arthrofibrosis or cardiac or dupuytren* or endomyocardial or hand or hands or heart orjoint orjoints or knee or knees or lung or lungs or myocardial or pulmonary or shoulder).ti,ab,hw,kw.	8,874,025
18	11 and (1 or 5)	133
19	12 and (1 or (5 and 10))	607
20	13 and (1 or (5 and 10))	91
21	14 and (1 or (5 and 10))	103
22	15 and (1 or (5 and 10))	118
23	16 and (1 or 5)	1933
24	(arthrofibroses or arthrofibrosis or fibroses or fibrosis).ti. and 10 and (arthrofibroses or arthrofibrosis or cardiac or dupuytren* or endomyocardial or hand or hands or heart or joint or joints or knee or knees or lung or lungs or myocardial or pulmonary or shoulder).ti.	8844
25	1 and 17	346
26	2 or 3 or 4 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25	12,326
27	(case* adj3 report*).mp,pt.	4,842,191
28	exp Genetic Diseases, Inborn/	1,707,136
29	(“Alagille Syndrome*” or “alpha 1-Antitrypsin Deficienc*” or “Ataxia Telangiectasia*” or “Autoimmune Lymphoproliferative Syndrome*” or “Brugada Syndrome*” or CADASIL or “Camurati-Engelmann Syndrome*” or “CHARGE Syndrome*” or Cherubism or “Chromosome disorder*” or Ciliopath* or “congenital Adrenal Hyperplasia*” or “congenital Angioedema*” or “congenital Autoinflammatory Disease*” or “congenital Eye Disease*” or “congenital hemolytic Anemia*” or “congenital hypertrophic Cardiomyopath*” or “congenital hypoplastic Anemia*” or “congenital Multiple Lipomatos*” or “Congenital Myasthenic Syndrome*” or “congenital NeoplasticNeoplastic Syndrome*” or “Congenital Pain Insensitivity” or “Costello Syndrome*” or “Cystic Fibros*” or “Donohue Syndrome*” or Dwarfism or “familial Adrenal Hyperplasia*” or “familial Angioedema*” or “familial Autoinflammatory Disease*” or “familial Eye Disease*” or “familial hemolytic Anemia*” or “familial hypertrophic Cardiomyopath*” or “familial hypoplastic Anemia*” or “Familial Multiple Lipomatos*” or “familial Myasthenic Syndrome*” or “familial NeoplasticNeoplastic Syndrome*” or “familial Pain Insensitivity” or “Frasier Syndrome*” or “GATA2 Deficienc*” or “genetic Skin Disease*” or “Graves Ophthalmopath*” or “Hajdu-Cheney Syndrome*” or Hemoglobinopath* or “hereditary Adrenal Hyperplasia*” or “hereditary Angioedema*” or “Hereditary Autoinflammatory Disease*” or “hereditary Eye Disease*” or “hereditary hemolytic Anemia*” or “hereditary hypertrophic Cardiomyopath*” or “hereditary hypoplastic Anemia*” or “hereditary Multiple Lipomatos*” or “hereditary Myasthenic Syndrome*” or “Hereditary NeoplasticNeoplastic Syndrome*” or “hereditary Pain Insensitivity” or “Heredodegenerative disorder*” or “Hyper-IgM Immunodeficiency Syndrome*” or “Inborn Errors of Metabolism” or “inborn Genetic Disease*” or “inherited Blood Coagulation disorder*” or “Kallmann Syndrome*” or “Kartagener Syndrome*” or “Lennox Gastaut Syndrome*” or “Loeys-Dietz Syndrome*” or “Marfan Syndrome*” or “Muscular Dystroph*” or “Nail-Patella Syndrome*” or “Oculocerebrorenal Syndrome*” or “Orofaciodigital Syndrome*” or Osteochondrodysplasia* or “Osteogenesis Imperfecta” or “Pelger-Huet Anomaly” or “Primary hypertrophicOsteoarthropath*” or Pycnodysostos* or “rheumatoid disease*” or scleroderma* or “Werner Syndrome*” or “X-Linked Genetic Disease*” or “Yellow Nail Syndrome*” or “Y-Linked Genetic Disease*”).ti,ab,hw,kw.	471,956
30	exp Atrial Fibrillation/	116,660
31	“atrial fibrillation*”.ti,ab,hw,kw.	223,252
32	exp Sarcoidosis/	58,514
33	sarcoidosis.ti,ab,hw,kw.	70,450
34	Myositis/	22,687
35	myositis.ti,ab,hw,kw.	37,853
36	exp Epigenomics/	74,627
37	(epigenetic* or epigenomic*).ti,ab,hw,kw.	208,463
38	exp Smoking/	520,985
39	smoking.ti,ab,hw,kw.	761,622
40	or/27–39	7,503,536
41	26 not 40	8531
42	limit 41 to english language [Limit not valid in CDSR; records were retained]	8210
43	limit 42 to yr=“2000 -Current”	7798
44	(exp animals/ or exp nonhuman/) not exp humans/	10,852,970
45	((alpaca or alpacas or amphibian or amphibians or animal or animals or antelope or armadillo or armadillos or avian or baboon or baboons or beagle or beagles or bee or bees or bird or birds or bison or bovine or buffalo or buffaloes or buffalos or “c elegans” or “Caenorhabditis elegans” or camel or camels or canine or canines or carp or cats or cattle or chick or chicken or chickens or chicks or chimp or chimpanze or chimpanzees or chimps or cow or cows or “D melanogaster” or “dairy calf” or “dairy calves” or deer or dog or dogs or donkey or donkeys or drosophila or “Drosophila melanogaster” or duck or duckling or ducklings or ducks or equid or equids or equine or equines or feline or felines or ferret or ferrets or finch or finches or fish or flatworm or flatworms or fox or foxes or frog or frogs or “fruit flies” or “fruit fly” or “G mellonella” or “Galleria mellonella” or geese or gerbil or gerbils or goat or goats or goose or gorilla or gorillas or hamster or hamsters or hare or hares or heifer or heifers or horse or horses or insect or insects orjellyfish or kangaroo or kangaroos or kitten or kittens or lagomorph or lagomorphs or lamb or lambs or llama or llamas or macaque or macaques or macaw or macaws or marmoset or marmosets or mice or minipig or minipigs or mink or minks or monkey or monkeys or mouse or mule or mules or nematode or nematodes or octopus or octopuses or orangutan or “orang-utan” or orangutans or “orang-utans” or oxen or parrot or parrots or pig or pigeon or pigeons or piglet or piglets or pigs or porcine or primate or primates or quail or rabbit or rabbits or rat or rats or reptile or reptiles or rodent or rodents or ruminant or ruminants or salmon or sheep or shrimp or slug or slugs or swine or tamarin or tamarins or toad or toads or trout or urchin or urchins or vole or voles or waxworm or waxworms or worm or worms or xenopus or “zebra fish” or zebrafish) not (human or humans or patient or patients)).ti,ab,hw,kw.	9,357,844
46	43 not (44 or 45)	4075
47	limit 46 to (letter or conference abstract or editorial or erratum or note or addresses or autobiography or bibliography or biography or blogs or comment or dictionary or directory or interactive tutorial or interview or lectures or legal cases or legislation or news or newspaper article or overall or patient education handout or periodical index or portraits or published erratum or video-audio media or webcasts) [Limit not valid in CCTR, CDSR,Embase, Ovid MEDLINE(R),Ovid MEDLINE(R) Daily Update, Ovid MEDLINE(R) In-Process,Ovid MEDLINE(R) Publisher; records were retained]	976
48	46 not 47	3099
49	remove duplicates from 48	2390