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. 2021 Jan 28;16(1):e0245387. doi: 10.1371/journal.pone.0245387

Table 1. Characteristics of study population by degree of prematurity.

Extremely Preterm (<30 weeks) Moderately Preterm (30–33 weeks) Late Preterm (34–36 weeks) Total Population
N = 548 (21.34%) N = 751 (29.24%) N = 1,269 (49.42%) N = 2,568
n (%) n (%) n (%) n (%)
Maternal characteristics and clinical factors
Maternal race
    Asian 16 (2.92%) 17 (2.26%) 54 (4.26%) 87 (3.39%)
    Black/African American 75 (13.69%) 53 (7.06%) 109 (8.59%) 237 (9.23%)
     Multiple Race 12 (2.19%) 10 (1.33%) 22 (1.73%) 44 (1.71%)
    Other 35 (6.39%) 45 (5.99%) 99 (7.80%) 179 (6.97%)
    Unknown 19 (3.47%) 16 (2.13%) 33 (2.60%) 68 (2.65%)
    White 391 (71.35%) 610 (81.23%) 952 (75.02%) 1953 (76.05%)
Maternal ethnicity
    Hispanic or Latino 30–40 (<10%) 50–60 (<10%) 102 (8.04%) 187 (7.28%)
    Not Hispanic/Latino 455 (83.03%) 647 (86.15%) 1103 (86.92%) 2205 (85.86%)
    Other <10 (<10%) <10 (<10%) 19 (1.50%) 35 (1.36%)
    Unknown 49 (8.94%) 47 (6.26%) 45 (3.55%) 141 (5.49%)
Mother’s age (years) 29.26 ± 5.96 29.76 ± 5.87 30.02 ± 5.66 29.78 ± 5.79
Maternal primary insurance at delivery
    Medicaid 187 (34.12%) 233 (31.03%) 339 (26.71%) 759 (29.56%)
    Medicare <10 (<15%) <10 (<10%) 12 (0.95%) 22 (0. 68%)
    Other 14 (2.55%) 23 (3.06%) 32 (2.52%) 69 (2.69%)
    Private 285 (52.01%) 418 (55.66%) 755 (59.50%) 1458 (56.78%)
    Unknown 60–70 (<15%) 60–70 (<10%) 131 (10.32%) 260 (10.12%)
Maternal first trimester BMI
    Underweight <10 (<10%) <15 (<10%) 23 (1.81%) 39 (1.52%)
    Normal BMI 196 (35.77%) 296 (39.28%) 461 (36.33%) 952 (37.07%)
    Overweight <150 (<25%) <180 (<25%) 327 (25.77%) 635 (24.73%
    Obese 212 (38.69%) 272 (36.22%) 458 (36.09%) 942 (36.68%)
Chorioamnionitis 76 (13.87%) 44 (5.86%) 38 (2.99%) 158 (6.15%)
Depression during pregnancy or prior to child’s discharge 106 (19.34%) 131 (17.44%) 209 (16.47%) 446 (17.37%)
Diabetes during pregnancy 62 (11.31%) 143 (19.04%) 308 (24.27%) 513 (19.98%)
Hypertension during pregnancy 86 (15.69%) 216 (28.76%) 353 (27.82%) 655 (25.51%)
Preeclampsia 88 (16.06%) 233 (31.03%) 338 (26.64%) 659 (25.66%)
Birth and neonatal characteristics
Sex
    Female 297 (54.20%) 339 (45.14%) 546 (43.03%) 1182 (46.03%)
    Male 251 (45.80%) 412 (54.86%) 723 (56.97%) 1386 (53.97%)
Birth year
    2009 32 (5.84%) 44 (5.86%) 80 (6.30%) 156 (6.07%)
    2010 60 (10.95%) 92 (12.25%) 132 (10.40%) 284 (11.06%)
    2011 58 (10.58%) 57 (7.59%) 131 (10.32%) 246 (9.58%)
    2012 58 (10.58%) 91 (12.12%) 157 (12.37%) 306 (11.92%)
    2013 65 (11.86%) 81 (10.79%) 125 (9.85%) 271 (10.55%)
    2014 63 (11.50%) 87 (11.58%) 160 (12.61%) 310 (12.07%)
    2015 66 (12.04%) 93 (12.38%) 143 (11.27%) 302 (11.76%)
    2016 72 (13.14%) 106 (14.11%) 137 (10.80%) 315 (12.27%)
    2017 64 (11.68%) 82 (10.92%) 167 (13.16%) 313 (12.19%)
    2018 10 (1.82%) 18 (2.40%) 37 (2.92%) 65 (2.53%)
Multiples 144 (26.28%) 278 (37.02%) 376 (29.63%) 798 (31.07%)
Delivery Type
    Cesarean Section 367 (66.97%) 486 (64.71%) 675 (53.19%) 1528 (59.50%)
    Vaginal 181 (33.03%) 265 (35.29%) 594 (46.81%) 1040 (40.50%)
Birth length (cm) 34.51 ± 3.96 42.39 ± 3.47 46.83 ± 2.80 42.90 ± 5.78
Birth weight (gr) 951.61 ± 298.47 1747.17 ± 416.31 2536.43 ± 506.99 1967.42 ± 768.84
Head circumference (cm) 24.36 ± 2.75 29.69 ± 2.18 32.54 ± 1.73 29.96 ± 3.81
1-minute Apgar score 5 ± 2 6 ± 2 7 ± 2 6 ± 2
Length of birth hospitalization stay (days) 89.80 ± 40.18 36.36 ± 22.37 11.64 ± 10.55 35.55 ± 38.16
Neonatal morbidities and treatments
Atrial septal defects 323 (58.94%) 136 (18.11%) 122 (9.61%) 581 (22.62%)
BPD 412 (75.18%) 75 (9.99%) 17 (1.34%) 504 (19.63%)
Hypoglycemic 243 (44.34%) 407 (54.19%) 690 (54.37%) 1340 (52.18%)
Hyperglycemic 215 (39.23%) 65 (8.66%) 32 (2.52%) 312 (12.15%)
IVH 97 (17.70%) 50–60 (<10%) <10 (<10%) 154 (6.00%)
NEC 20 (3.65%) 10–20 (<10%) <10 (<10%) 40 (1.56%)
PDA 280 (51.09%) 41 (5.46%) 29 (2.29%) 350 (13.63%)
PVL 22 (4.01%) <10 (<10%) <10 (<10%) 29 (1.13%)
RDS 514 (93.80%) 412 (54.86%) 363 (28.61%) 1289 (50.19%)
ROP 219 (39.96%) 10–20 (<10%) <10 (<10%) 229 (8.92%)
Ventricular septal defects 22 (4.01%) 12 (1.60%) 26 (2.05%) 60 (2.34%)
TPN 536 (97.81%) 684 (91.08%) 256 (20.17%) 1476 (57.48%)

Abbreviations: BPD, bronchopulmonary dysplasia; IVH, intraventricular hemorrhage; NEC, necrotizing enterocolitis; PDA, patent ductus arteriosus; PVL, periventricular leukomalacia; RDS, respiratory distress syndrome; ROP, retinopathy of prematurity; TPN, total parenteral nutrition; gr, grams; cm, centimeters.

Values given as a range, as data is suppressed due to counts less than 10 or to protect confidentiality.

Data are expressed as mean ± standard deviation.