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. 2021 Jan 28;16(1):e0245387. doi: 10.1371/journal.pone.0245387

Table 2. Multivariable model with and without clustering in all preterm infants.

Un-clustered Clustered on familial relation
Variable Parameter estimate(s) SE P-value Parameter estimate(s) SE P-value
Intercept 11.02142 5.68115 0.0525 10.60334 5.63184 0.0598
Maternal race
    Asian -0.15719 0.03980 <0.0001* -0.15903 0.03946 <0.0001*
    Black/African American 0.00283 0.02518 0.9105 0.00383 0.02496 0.8779
    Multiple races -0.09668 0.05513 0.0796 -0.09575 0.05465 0.0799
    Other -0.00151 0.02850 0.9579 -0.00227 0.02826 0.9361
    Unknown -0.02251 0.04450 0.6130 -0.01815 0.04412 0.6808
Maternal first trimester BMI
    Underweight -0.10882 0.05894 0.0650 -0.11562 0.05843 0.0479
    Overweight 0.01170 0.01860 0.5294 0.00848 0.01843 0.6456
    Obese 0.03154 0.01762 0.0736 0.02956 0.01747 0.0908
Maternal hypertension during pregnancy -0.00294 0.01909 0.8777 -0.00360 0.01892 0.8492
Preeclampsia 0.00653 0.01859 0.7256 0.00851 0.01843 0.6444
Birth year -0.00552 0.00282 0.0507 -0.00531 0.00280 0.0578
Multiple(s) 0.02730 0.01593 0.0867 0.03036 0.01579 0.0547
Gestational age (weeks) 0.01599 0.00569 0.0049* 0.01543 0.00564 0.0062*
Birth weight (gr) -0.00002 0.00003 0.4994 -0.00002 0.00003 0.5108
Birth length (cm) -0.00022 0.00337 0.9469 0.00008 0.00334 0.9802
Head circumference (cm) -0.00915 0.00529 0.0837 -0.00894 0.00524 0.0884
TPN -0.02370 0.02119 0.2634 -0.02204 0.02100 0.2941
Received dextrose 0.03910 0.01818 0.0316* 0.03780 0.01802 0.0361*
Length of birth hospitalization stay (days) -0.00029 0.00037 0.4378 -0.00029 0.00037 0.4307

Abbreviations: BMI, body mass index; cm, centimeters; gr, grams; SE, standard error; TPN, total parenteral nutrition.

Referent groups: White maternal race, normal maternal first trimester BMI, no hypertension, no preeclampsia, singleton, no TPN, no dextrose.

*p<0.05. P-values were calculated using multivariable linear regression.