Fig 6. Simulations of age-related changes in oxygen tension at different cortical depths: 120, 280, 480, 680, and 880μm.

(Top Row) young normal brain, (Second Row) aged brain with capillary micro-occlusions. (Third Row) aged brain with reduced systemic hematocrit, and (Bottom Row) aged brain with the combined aging effect of reduced hematocrit and micro-occlusions. The region of tissue containing low oxygen content greatly increase in the aged models. Hypoxic pockets form in the lower cortical region when the effect of hematocrit and micro-occlusions combine (aged Hct+Occl at 880μm). The white dotted regions delineate the formation of hypoxic regions.