Figure 5.

Representative structures of bilayer β-sheets and β-barrels of wild-type (a) and I149P mutant (b) hexamers at 310 K from the REMD simulations, shown in two different views: side view and top view. Different sizes of bilayer β-sheets are denoted by m + n, where m and n represent, respectively, the m- and n-stranded β-sheets forming the bilayer β-sheets. The four different β-barrels include four-, five-, and six-stranded open β-barrels (open B4, open B5, open B6) and six-stranded closed β-barrel (closed B6).