Table 1. Levels of plasma fasting glucose, insulin levels and HOMA-IR values in animals treated with risperidone and paliperidone.

Antipsychotic Drug	Measure	Treatment Dose (mg/kg)
Risperidone		0	0.1	0.5	1	2	6
	G0	5.5 ± 0.2	4.8 ± 0.1	5.7 ± 0.3	6.4 ± 0.4*	6.4 ± 0.3*	6.7 ± 0.3*
	I0	17.8 ± 2.2	25.9 ± 2.4	33.4 ± 4.9*	32.2 ± 3.4*	33.9 ± 6.0*	37.5 ± 1.7*
	HOMA-IR	4.3 ± 0.5	5.55 ± 0.5	8.2 ± 1.1*	9.2 ± 1.3*	9.6 ± 1.9*	11.2 ± 0.7*
Paliperidone		0	0.1	0.5	1	2	6
	G0	5.4 ± 0.2	5.4 ± 0.1	5.2 ± 0.4	5.8 ± 0.2	5.5 ± 0.2	6.4 ± 0.3*
	I0	14.9 ± 2.0	22.1 ± 2.3	33.8 ± 6.0*	33.9 ± 3.3*	31.3 ± 3.8*	34.8 ± 2.5*
	HOMA-IR	3.5 ± 0.5	5.3 ± 0.5	8.1 ± 1.6*	8.9 ± 2.8*	7.8 ± 1.0*	9.9 ± 0.9*

G₀ = fasting glucose levels (mmol/L); I₀ = fasting insulin levels (μU/ml); HOMA-IR = Homeostatic Model Assessment of Insulin Resistance (μU·mmol) / (ml·L). Adult female rats (n = 8–9 per group) were treated with five separate doses of risperidone, paliperidone or vehicle. Values are group means ± SEM. Measurement occurred at t = 30 min of the intraperitoneal glucose tolerance test.

* statistically different from control animals, p < 0.05.