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. 2021 Mar 4;184(5):1171–1187.e20. doi: 10.1016/j.cell.2021.01.037

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S3 — Virological and clinical results stratified by positions 439 and 614, related to Figures 3 and 5

(A) Phylodynamic analysis showing lineage growth rates relative to sampling times for UK lineages in Scotland. Data used for analysis were sampled between Feb 28, 2020 and Aug 18, 2020 (see STAR methods and http://sars2.cvr.gla.ac.uk/RiseFallScotCOVID/). The Scottish N439K lineage i (which co-occurs with D614G) is indicated in black along with whether wild-type N439 lineages are D614 (red) or D614G (blue). The inset shows a boxplot for the distributions of these genotypes. Note, only the growth rates between −50 and 50 are plotted.

(B) Comparison of clinical severity between D614/N439, D614G/N439 and D614G/N439K genotypes by patient age group for 1591 patients whose diagnostic samples were sequenced. Ordinal scale scored by oxygen requirement: 1. No respiratory support, 2: Supplemental oxygen, 3: Invasive or non-invasive ventilation or oxygen delivery by high flow nasal cannulae, 4: Death.