Table 3.
Association of baseline characteristics, findings on admission and adverse events with mortality: crude OR and adjusted to Charlson-Age Index OR.
| OR | 95% CI | p | Adjusted OR | 95% CI | p | |
|---|---|---|---|---|---|---|
| Demographic characteristics | ||||||
| Age | 1.007 | 1.058–1.097 | 0.000 | |||
| Gender: male | 1.395 | 0.926–2.100 | 0.111 | 1.611 | 1.035–2.509 | 0.035 |
| BMI | 0.969 | 0.898–1.047 | 0.427 | 0.983 | 0.907–1.066 | 0.683 |
| Charlson Age Index | 1.477 | 1.343–1.625 | 0.000 | |||
| Symptoms on admission | ||||||
| Dyspnea | 2.706 | 1.662–4.406 | 0.000 | 2.651 | 1.582–4.442 | 0.000 |
| Dysgeusia/anosmia | 0.150 | 0.036–0.627 | 0.000 | 0.218 | 0.051–0.933 | 0.040 |
| Arthralgia/myalgia | 0.157 | 0.082–0.300 | 0.000 | 0.199 | 0.102–0.388 | 0.000 |
| Asthenia | 0.412 | 0.277–0.612 | 0.000 | 0.426 | 0.278–0.652 | 0.000 |
| Cough | 0.572 | 0.380–0.860 | 0.007 | 0.869 | 0.556–1.356 | 0.536 |
| High Temperature | 0.965 | 0.605–1.539 | 0.881 | 2.170 | 1.257–3.745 | 0.005 |
| Diarrhea | 0.662 | 0.396–1.107 | 0.116 | 0.735 | 0.422–1.281 | 0.278 |
| Vomiting | 0.829 | 0.418–1.644 | 0.591 | 0.925 | 0.436–1.965 | 0.840 |
| Vital signs on admission | ||||||
| Blood O2 saturation <92% | 5.615 | 3.671–8.587 | 0.000 | 5.359 | 3.395–8.461 | 0.000 |
| Tachypnea (>22 bpm) | 3.036 | 1.984–4.646 | 0.000 | 3.424 | 2.159–5.434 | 0.000 |
| Disorder of conciousness | 5.147 | 2.929–9.047 | 0.000 | 2.792 | 1.529–5.098 | 0.001 |
| SBP<90 or/and DBP<60 mmHg | 3.319 | 1.755–6.277 | 0.000 | 2.660 | 1.341–5.277 | 0.000 |
| q-SOFA≥2 | 5.611 | 2.964–10.624 | 0.000 | 3.153 | 1.595–6.234 | 0.001 |
| Chest X-ray on admission | ||||||
| Bilateral infiltration | 1.257 | 0.661–2.391 | 0.485 | 2.522 | 1.215–5.236 | 0.013 |
| Laboratory findings on admission | ||||||
| Albumin <34 g/L | 3.109 | 2.066–4.978 | 0.000 | 2.050 | 1.323–3.178 | 0.001 |
| Lymphocytes ≤800/μL | 2.781 | 1.837–4.211 | 0.000 | 2.566 | 1.645–4.004 | 0.000 |
| Creatinine | 2.137 | 1.550–2.945 | 0.000 | 1.372 | 1.044–1.802 | 0.023 |
| D-Dimer >0.49 ng/dL | 2.390 | 1.229–4.647 | 0.010 | 1.752 | 0.876–3.507 | 0.113 |
| hs-CRP >8 mg/L | 8.193 | 1.105–60.755 | 0.040 | 12.045 | 1.502–96.577 | 0.019 |
| Lactate dehydrogenase >250 U/L | 2.712 | 1.316–5.589 | 0.007 | 3.457 | 1.621–7.375 | 0.001 |
| Hemoglobin | 0.849 | 0.776–0.928 | 0.000 | 1.025 | 0.923–1.139 | 0.641 |
| Leucocyte count | 1.000 | 1.000–1.000 | 0.054 | 1.000 | 1.000–1.000 | 0.257 |
| Platelet count | 1.000 | 1.000–1.000 | 0.013 | 1.000 | 1.000–1.000 | 0.049 |
| Fibrinogen | 0.999 | 0.987–1.011 | 0.839 | 1.000 | 0.988–1.012 | 0.937 |
| Sodium | 1.019 | 0.971–1.070 | 0.437 | 1.009 | 0.964–1.055 | 0.711 |
| AST | 1.001 | 0.995–1.006 | 0.792 | 1.004 | 0.998–1.010 | 0.161 |
| Ferritin | 1.000 | 1.000–1.001 | 0.203 | 1.000 | 1.000–1.001 | 0.059 |
| Adverse events | ||||||
| ARDS | 20.717 | 12.015–33.864 | 0.000 | 31.699 | 16.843–59.660 | 0.000 |
| Sepsis | 21.386 | 9.596–47.659 | 0.000 | 20.994 | 9.049–48.710 | 0.000 |
| Acute Respiratory Failure | 10.651 | 3.854–29.434 | 0.000 | 12.349 | 4.280–35.631 | 0.000 |
| Bilateral Pneumonia | 1.861 | 1.186–2.921 | 0.007 | 4.244 | 1.610–4.257 | 0.003 |
| Acute Kidney Injury | 5.452 | 3.538–8.403 | 0.000 | 2.970 | 1.838–4.800 | 0.000 |
| MAS | 1.396 | 0.932–2.083 | 0.106 | 2.121 | 1.354–3.322 | 0.001 |
| Acute Heart Failure | 2.501 | 1.399–4.470 | 0.002 | 0.895 | 0.459–1.744 | 0.743 |
| Bleeding events | 1.196 | 0.467–3.059 | 0.709 | 0.678 | 0.245–1.880 | 0.455 |
| Embolic events | 2.725 | 1.016–7.306 | 0.046 | 2.906 | 0.981–8.609 | 0.054 |
ARDS: acute respiratory distress syndrome. BMI: body mass index. hs-CRP: high sensiticity C-reactive protein. MAS: macrophage activation syndrome. DBP: diastolic blood pressure. q-SOFA: quick-Sequential Organ Failure score. SBP: systolic blood pressure.