Figure 1. Pancreatic duct injection of acetic acid destroys the exocrine pancreas, but spares the islets.

Saleh and colleagues injected saline or acetic acid (0.2%) into the pancreatic duct of mice. The pancreatic histology appeared normal in saline-injected pancreas. In contrast, six months following acetic acid injection, the acinar and duct cells appeared absent, while the islets looked healthy (12).