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. 2021 Feb 1;131(3):e139333. doi: 10.1172/JCI139333

Figure 8. Tumor growth suppression mediated by ATM deficiency is dependent on T cells.

Figure 8

(A and B) Tumor volume (A) and Kaplan-Meier survival curves (B) for C57BL/6 mice inoculated with approximately 1 × 105 vector control or Atm-KO B16F10 cells and treated with 100 μg/mouse anti-CD8 or isotype control on days 1, 4, and 7. (C and D) Tumor volume (C) and Kaplan-Meier survival curves (D) for C57BL/6 mice inoculated with approximately 1 × 105 vector control or Atm-KO B16F10 cells and treated with 100 μg/mouse anti-CD4 or isotype control on days 1, 4, and 7. (E and F) Tumor volume (E) and Kaplan-Meier survival curves (F) for C57BL/6 mice inoculated with approximately 1 × 105 vector control or Atm-KO B16F10 cells and treated with 100 μg/mouse anti-NK1.1 or isotype control on days 1, 4, and 7. The vector control and Atm-KO groups are the same for A–F. Data are presented in separate panels for easy visualization. Data represent the mean ± SEM. **P < 0.01 and ****P < 0.0001, by unpaired t test (A, C, and E) or log-rank test (B, D, and F).