Skip to main content
. 2021 Feb 1;131(3):e142434. doi: 10.1172/JCI142434

Figure 1. Improved clinical outcomes in atypical DOCK8-deficient patients over time.

Figure 1

(A–C) Serum was collected at different time points from 2 atypical DOCK8-deficient patients (P1: circles, top; P3: triangles, bottom) and was tested by ImmunoCAP assay for concentrations of (A) total, (B) staple food–specific, and (C) dust mite–specific IgE. Dotted line indicates average value of healthy donors (n = 3–5). (D) EBV viral load in peripheral blood of P3 was assessed at numerous time points. The dashed line indicates the limit of detection. (E) Eosinophil numbers in peripheral blood of P3 were assessed at numerous ages. Error bars indicate SEM and the shaded area indicates references ranges for healthy age-matched donors. (F) Clinical score based on the NIH scoring system (26) was calculated for DOCK8-deficient patients (n = 53) and for patients P1, P2, and P3 at various ages.