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. 2021 Feb 1;131(3):e142434. doi: 10.1172/JCI142434

Figure 6. Diversity of the TCR repertoire is not improved in DOCK8-revertant patients.

Figure 6

TCR beta genes were sequenced from genomic DNA from healthy donors (n = 3), DOCK8-revertant patients (P1, P2 at 2 time points, P3 at 3 time points), and DOCK8-deficient patients (n = 3). TCR repertoire diversity was estimated in all samples after down-sampling transformation (23,838 sequences) by (A) plotting the observed diversity (number of different clones in the down-sampled file) and (B) calculating the inverse Simpson index, which computes repertoire richness and evenness. Error bars represent SEM.