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. Author manuscript; available in PMC: 2021 Jan 29.
Published in final edited form as: J Mol Med (Berl). 2020 Jun 12;98(7):1009–1020. doi: 10.1007/s00109-020-01933-8

Figure 5. TP53 is a Potential Key Regulator of Hypoxia-Induced Transcriptome Reprogramming.

Figure 5.

A. Schematic representation of P53 transcriptional network. B. Volcano blots of TP53_regulated genes display reduced DGE in RV vs LV in neonatal mouse heart in hypoxia-treated neonatal mouse hearts compared to normoxia condition. C. IPA-based upstream analysis reveals TP53 as a key regulator of the DGE genes involved in epithelial-mesenchymal transition and extracellular matrix remodeling. D. Correlation plot depicts significant concordance of TP53 -target gene expression in hypoxemic RVs from mouse and human TOF cases. E. Quantitative expression analysis (qRT-PCR) of TP53, TP53INP2, TP53RK in RV and LV myocardium of P3 neonatal mouse depicts robust induction in hypoxia-treated RVs compared to normoxia condition; n=3 per group per condition. *P ≤ 0.05, **P ≤ 0.01, (hypoxia compared to normoxia condition).