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. 2021 Jan 29;116(1):6. doi: 10.1007/s00395-021-00847-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Interaction between platelets and NGPs. a Sema7A influences megakaryopoiesis and reduces differentiation and megakaryocyte and platelet production. It also interacts with the platelet GPIb receptor and activates platelets through this receptor. b PlxB2 functions as a receptor for Sema4C and regulates the activation and thrombotic activity of platelets. c Sema3A interacts with PlxA1-3 and inhibits the secretion of granules and aggregation of platelets. d Sema4D phosphorylates glycoprotein VI and Syk as downstream targets of Clec-2. e Slit-2 was shown to inhibit platelet adhesion, aggregation and granule secretion via the Robo-1 receptor (with Sema Semaphorin, Plx Plexin)