Skip to main content
. 2020 Nov 7;35(1):e23575. doi: 10.1002/jcla.23575

TABLE 1.

Clinical characteristics of BC patients in diagnostic studies on circRNAs

Study Sample size Control source CircRNA type Test method/ References CircRNA level Cutoff value TP FP FN TN
BC Control
Li Y 2019 23 350 (0‐II: 266) 163 Paired adjacent tissue Circ‐VRK1 qRT‐PCR/2−△△Ct method/GAPDH Down‐regulated 0.425 217 34 133 129
Yang R 2019 32 40 (0‐II: 33） 40 Healthy individuals circAGFG1 qRT‐PCR/2−△△Ct method/GAPDH Up‐regulated Unclear 26 4 14 36
Yin WB 2018 33 20 17 Healthy individuals hsa_circ_0001785 qRT‐PCR/2−△△Ct method/GAPDH Up‐regulated 0.981 16 4 4 13
Yin WB 2018 33 20 17 Healthy individuals hsa_circ_0108942 qRT‐PCR/2−△△Ct method/GAPDH Up‐regulated 0.981 16 8 4 9
Yin WB 2018 33 20 17 Healthy individuals hsa_circ_0068033 qRT‐PCR/2−△△Ct method/GAPDH Down‐regulated 0.981 15 7 5 10
Yin WB 2018 33 57 (0‐II: 21) 17 Healthy individuals hsa_circ_0001785 qRT‐PCR/2−△△Ct method/GAPDH Up‐regulated 0.981 44 5 13 12
Lü L 2017 25 51 (0‐II: 46) 51 Adjacent noncancer tissue hsa_circ_103110 qRT‐PCR/ΔCt method GAPDH Down‐regulated 8.97 32 19 19 32
Lü L 2017 25 51(0‐II: 46) 51 Adjacent noncancer tissue hsa_circ_104689 qRT‐PCR/ΔCt method GAPDH Down‐regulated 7.67 29 23 22 28
Lü L 2017 25 51(0‐II: 46) 51 Adjacent noncancer tissue hsa_circ_104821 qRT‐PCR/ΔCt method GAPDH Down‐regulated 6.04 29 22 22 29
Lü L 2017 25 51(0‐II: 46) 51 Adjacent noncancer tissue hsa_circ_006054 qRT‐PCR/ΔCt method GAPDH Up‐regulated 14.84 33 16 18 35
Lü L 2017 25 51(0‐II: 46) 51 Adjacent noncancer tissue hsa_circ_100219 qRT‐PCR/ΔCt method GAPDH Up‐regulated 8.95 35 15 16 36
Lü L 2017 25 51(0‐II: 46) 51 Adjacent noncancer tissue hsa_circ_406697 qRT‐PCR/ΔCt method GAPDH Up‐regulated 14.24 32 19 19 32

Abbreviations: BC, breast cancer; circRNA, circular RNA; FN, false negative; FP, false positive; GAPDH, reduced glyceraldehyde‐phosphate dehydrogenase; qRT‐PCR, quantitative reverse transcription‐polymerase chain reaction; TN, true negative; TP, true positive.