Table 2.

Univariate and multivariate analysis for evaluation of potential predictors associated with melanoma recurrence

Potential predictor	Univariate association (HR, 95% CI, p value)		Multivariable association (HR, 95% CI, p value)
Male gender (reference female)	0.31 (0.11 to 0.94), p=0.038*		0.48 (0.15 to 1.57), p=0.228
Age (per 10 years)	0.71 (0.56 to 0.89), p=0.004*		0.76 (0.59 to 0.98), p=0.037*
Pre-PD-1 NLR	1.10 (0.88 to 1.37), p=0.426		–
Pre-PD-1 LDH (per 50 U/L)	0.98 (0.78 to 1.24), p=0.882		–
History of brain metastasis (reference no history)	5.83 (1.78 to 19.04), p=0.004 *		4.91 (1.50 to 16.11), p=0.009*
Post-PD-1 NLR	1.03 (0.70 to 1.53), p=0.872		–
Post-PD-1 LDH (per 50 U/L)	2.19 (1.20 to 4.02), p=0.011*		2.06 (1.06 to 4.00), p=0.032*
Best objective response (reference CR)	PR 1.65 (0.34 to 7.99), p=0.531	Overall p=0.403	–
	SD 2.96 (0.54 to 16.27), p=0.211

*p values <0.05.

CR, complete response; LDH, lactate dehydrogenase; NLR, neutrophil–lymphocyte ratio; PD-1, programmed cell death protein 1; PR, partial response; SD, stable disease.