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. 2021 Jan 15;11:565869. doi: 10.3389/fimmu.2020.565869

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Copyright © 2021 Machata, Sreekantapuram, Hünniger, Kurzai, Dunker, Schubert, Krüger, Schulze-Richter, Speth, Rambach and Jacobsen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Survival and association of C. albicans with leukocytes in murine whole blood. Colony forming units (CFU) were determined from infected blood of BALB/c (A) and C57BL/6J (B) mice. Each dot represents the data from an independent experiment; lines represent mean ± standard deviation (n = 3, except BALB/c 90 min and 120 min: n = 2). (C, D) The percentage of GFP-expressing Candida binding to immune cells of blood was calculated relative to total C. albicans cells in infected blood (set to 100%) during a time course of 3 h. All values correspond to the means of three independent experiments with pooled whole blood from 10 mice. Left: BALB/c; right: C57BL/6. (E, F) The percentage of various immune cells associated with Candida was determined relative to their overall cell population in the blood. All values correspond to the means of three independent experiments with pooled whole blood from 10 mice. Left: BALB/c; right: C57BL/6.