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. 2021 Jan 15;11:565869. doi: 10.3389/fimmu.2020.565869

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Copyright © 2021 Machata, Sreekantapuram, Hünniger, Kurzai, Dunker, Schubert, Krüger, Schulze-Richter, Speth, Rambach and Jacobsen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C. albicans-induced platelet activation and aggregation (A) Fungal interactions with platelets were visualized in blood smears of ex vivo infected murine whole blood after staining with Mai-Gruenwald- Giemsa. Aggregates of thrombocytes (black arrow) surround Candida (white arrow) mostly during the first hour of infection. Flow cytometry analysis shows (B) strong binding of C. albicans to platelets almost immediately after infection and (C) induced expression of CD69 on the surface of platelets. Asterisks indicate significant differences (p<0.05; 1-Way ANOVA and Holm-Sidak’s multiple comparison test to compare each infected time point to 0 min).