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. 2021 Jan 15;11:565869. doi: 10.3389/fimmu.2020.565869

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Copyright © 2021 Machata, Sreekantapuram, Hünniger, Kurzai, Dunker, Schubert, Krüger, Schulze-Richter, Speth, Rambach and Jacobsen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Platelet activation in mice systemically infected with C. albicans. (A) The number of circulating platelets in peripheral murine blood was determined with an automated hematology analyzer. Deposition of complement factor C3 (B), fibrinogen (C), and surface expression of CD63 (D) and CD62P (E) was quantified by flow cytometry. (F) Soluble CD62 was measured in plasma by ELISA. CTRL: Samples from non-infected control animals. Time on X axis: Time after infection. Four to seven samples were analyzed per time point, data is presented as individual data points with bars indicating the mean ± standard deviation. Asterisks indicate significant differences (p<0.05; 1-Way ANOVA and Holm-Sidak’s multiple comparison test to compare each infected group to the control).