Table 1.

Summary of the key differences between the murine and human whole-blood model for C. albicans.

	Murine whole blood	Human whole blood
C. albicans killing	Not detectable	≥50% within 60 min, ≥80% within 180 min (4)
Association C. albicans with leukocytes	Approx. 40–60% max. (mouse strain-dependent)	Approx. 80% max (4).
Association with neutrophils relative to all leukocytes	≥50% (time point-dependent)	≥80% (4)
Association with monocytes relative to all leukocytes	≥25% (time point-dependent)	≤15% (4)
Association with lymphocytes relative to all leukocytes	≥50% (time point-dependent)	Not detectable (4)
% association neutrophils with C. albicans	40–50% (mouse strain-dependent)	Not determined
Filamentation (% hyphae)	≥60% after 60 min; ≥ 90% after 180 min	≤10% after 60 min; ≤20% after 180 min
Interaction with platelets
C. albicans association with platelets in whole blood	≤60% after 10 min; 40% after 180 min	≤10%