Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 15;10:593615. doi: 10.3389/fonc.2020.593615

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Jiang, Gao, Lan, Wang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

TIPE1 decreases CDDP sensitivity both in vitro and in vivo. (A, B) TIPE1-sh overexpression significantly increased CDDP-induced cytotoxicity in CDDP-resistant cervical cancer cells. (C, D) Overexpression of TIPE1-sh enhanced CDDP-induced apoptosis by flow cytometry. (E) Xenograft tumor models with SiHa/CDDP cells containing TIPE1-sh had an overall reduction in tumor volume compared to that in the control with or without CDDP treatment (CDDP 30 ug/kg). (F) TUNEL staining confirmed that TIPE1-sh increased CDDP-induced apoptosis. (G) TIPE1-sh increased the expression level of caspase-3, as detected by using an immunohistochemistry assay. Animal experiments were repeated twice with similar results and at least three mice were included in each group. Values represent means ± SD; for all panels, ***p < 0.001.