Figure 1.

Increased Fg in colons of DSS-induced colitis and UC patients. (A–C) 3% DSS was administered in drinking water to C57BL/6 mice for 7 days and replaced with drinking water thereafter. On day 7 and day 10, colons were collected and protein levels were measured by (A) quantitative proteomics, (B) immunoblotting, and (C) immunohistochemistry. Scale bar = 50 μm. n = 3 mice/group. (D) Fg level in colons of control (NC) and UC patients was measured by immunofluorescence staining. n = 10 (NC), n = 12 (UC patients). For B–D, densitometric analysis of Fg expression were displayed on the right. Scale bar = 50 μm. In A–D, data are presented as mean ± SEM. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001 (2-tailed unpaired Student’s t test).