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. 2021 Jan 15;11:604591. doi: 10.3389/fimmu.2020.604591

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Copyright © 2021 Rodriguez, Lalinde Ruiz, Llano León, Martínez Enríquez, Montilla Velásquez, Ortiz Aguirre, Rodríguez Bohórquez, Velandia Vargas, Hernández and Parra López

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study flow diagram. The search strategy performed in this article led to the initial selection of 418 potential papers. 303 were retrieved from PUBMED/MEDLINE, 115 from EBSCO and 0 from BVS in the identification phase. After duplicates were removed, a total of 263 papers were identified. From these, 157 articles were excluded based on title and abstract. Further investigation of the remaining 106 full text articles led to the exclusion of 70 articles and the inclusion of 36 studies for the qualitative synthesis among which 4 studies allowed us to perform a meta-analysis.