Table 1.

Characteristics of studies reporting memory subsets.

No.	References	Year	Lymphocyte definition	Elderly	Young	CMV status	Memory definition	Stimulation	Elderly (mean ± SD, %)				Young (mean ± SD, %)
				n	n				N	CM	EM	E	N	CM	EM	E
1	Xu et al. (15)	2019	γ/δ	12	12	Yes	CD27 CD45RA	No	↓	NS	NS	↑	↑	NS	NS	↓
2	Sizzano et al. (17)	2018	CD4/CD8	7	7	No	CCR7 CD45RO	No	NS	NS	NS	NS	NS	NS	NS	NS
3	Bajwa et al. (18)	2017	CD4/CD8	103	48	Yes	CD27 CD45RA	No	NC	NC	NC	NC	NC	NC	NC	NC
4	Riddell et al. (20)	2015	CD8	125		Yes	CD27 CD45RA	No	↓	NS	NS	↑	↑	NS	NS	↓
5	Henson et al. (21)	2015	CD8	8	8	No	CD27 CD45RA	Yes	NC	NC	NC	NC	NC	NC	NC	NC
6	Britanova et al. (22)	2014	CD4/CD8	7	10	No	CD27 CD45RA	No	18,8 ± 12,6	NM	NM	NM	37,5 ± 8,1	NM	NM	NM
7	Larbi et al. (23)	2014	CD4/CD8	15	15	No	CD27 CD45RA	No	↓	NS	↑	↑	↑	NS	↓	↓
8	Dolfi et al. (25)	2013	CD8	5	5	No	CD27 CD45RA	No	↓	NC	NC	NC	↑	NC	NC	NC
9	Lee et al. (26)	2012	CD8	43	62	Yes	CCR7 CD45RA	No	NC	NC	NC	NC	NC	NC	NC	NC
10	Libri et al. (28)	2011	CD4	± 67	± 40	Yes	CD27 CD45RA	No	↓	↑	↑	↑	↑	↓	↓	↓
11	Czesnikiewicz-Guzik et al. (31)	2008	CD4/CD8	26	31	No	CCR7 CD45RA	No	↓	↓	↓	↑	↑	↑	↑	↓
12	Nasi et al. (32)	2006	CD4/CD8	10	12	No	CCR7 CD45RA	No	↓	↑	↑	NS	↑	↓	↓	NS
13	Alberti et al. (34)	2006	CD4	20	12	No	CD28 CD95	No	35,6+/- 2,3	45,9+/- 2,8	11,8+/- 1,3		55 +/- 3,6	34,8+/- 2,8	8+/- 2,4
14	Hong et al. (37)	2004	CD8	17	17	No	CCR7 CD45RA	No	9.5 +/- 2.6	NS	51.3 +/- 3.4	32.3 +/- 3.7	46.4 +/- 4.1	NS	28.2 +/- 2.8	18.0 +/- 2.5
15	Zanni et al. (45)	2003	CD8	10	10	No	CD28 CD95	No	3.6 +/- 1.4	42.3 +/- 6	54 +/- 6		40.6 +/- 5	36.6 +/- 5	16.8 +/- 9

1. Information on Vδ1, mean ± SD not reported, Y were CMV- and O were CMV+ ( Figure 1B ) 2. The significant difference in the percentages of CD4 and CD8 subsets was between young and semi supercentenarians ( Figure 1 ) 3. The distributions of CMV-specific CD4 and CD8 T cells among the memory compartments ( Figure S3A ) 4. Results from multiple linear regression fitting age and CMV response as covariates for CD8+ T cell subset composition (1B/ Table S1 ) 5. Senescent characteristics in the memory subsets ( Figure 1 ) 6. Values in CD8 ( Table 1 ) 7. Impact of aging on T cell phenotype and function, values in CD8 (2A and 2 B) 8. Senescent and inhibitory characteristics in the memory subsets ( Figure S1 ) 9. Association of CMV infection with the frequency of CD8+ T cell subsets in young and elderly people. ( Figure S1 ) 10. Frequencies of each population within total CD4+ T cells are represented by grouping via age and CMV status, changes in N, EM and E subsets were CMV dependent ( Figure 1C ) 11. Values in CD8 T cells ( Figures 3B, D ) 12. The old group is centenarian ( Figure 2 ) 13. Stimuli with PMA/ionomycin did not change CD95 and CD28 expression. Stimulation was carried out to analyze modifications in the intracellular production of cytokines ( Table 1 ) 14. ( Figure 1B ) 15. Stimuli with PMA/ionomycin did not change CD95 and CD28 expression. Stimulation was carried out to analyze modifications in the intracellular production of cytokines ( Table 1 ). The figures and tables correspond to the original article cited. N, naive; CM, central memory; EM, effector memory; E, effector; ↑, increased; ↓, reduced; NS, no changes or no significant changes between the groups; NM, not measured; NC, not compared between the groups; NR, not reported.