Table 2.
No. | References | Year | Lymphocyte definition | Elderly | Young | CMV status | Populations | Stimulation | Markers in elderly | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | n | CD28 | CD57 | KLRG1 | CD95 | PD1 | CTLA4 | TIM3 | p16 | p21 | Others | |||||||
1 | Xu et al. (15) | 2019 | γ/δ | 12 | 12 | Yes | Subsets | No | NM | ↑ | ↑ | NM | NM | NM | NM | NM | NM | ↑CD85j, ↑CD244+, NC : γH2AX |
2 | Ross et al. (16) | 2018 | CD4/CD8 | 10 | 9 | Yes | Total | No | ↓ | NM | NM | NM | NM | NM | NM | NM | NM | ↓CD31 |
3 | Onyema et al. (19) | 2015 | CD8 | 11 | 11 | No | Subsets | No | ↓ | ↑ | NM | NC | NC | NM | NM | NC | ↑ | ↑CD245, NC Bcl-2 |
4 | Henson et al. (21) | 2015 | CD8 | 8 | 8 | No | Subsets | Yes | NM | ↑ | ↑ | NM | ↑ | NM | NM | NM | NM | ↑ p38, ↑γH2AX |
5 | Canaday et al. | 2013 | CD4/CD8 | 24 | 24 | No | Total | Yes | NM | NM | NM | NM | ↓ | ↑ | ↓ | NM | NM | ↓ ICOS in CD4 ex vivo |
6 | Dolfi et al. (25) | 2013 | CD8 | ± 38 | ± 37 | No | Total/subsets | No | NM | ↑ | ↑ | NM | ↑ | NM | NM | NM | NM | ↑LAG-3 ↑2B4, ↑T-bet, ↑Eomes |
7 | Onyema O et al. (27) | 2012 | CD8 | 11 | 11 | Yes | Total/subsets | No | ↓ | ↑ | ↑ | NM | NM | NM | NM | ↑ | ↑ | |
8 | Libri et al. (28) | 2011 | CD4 | 25 | Yes | Subsets | No | NC | NC | NM | NM | NM | NM | NM | NM | NM | IL-7Rα, Bcl-2 | |
9 | Agius et al. (29) | 2009 | CD4 | ± 9 | ± 11 | No | Total | No | NM | NM | NM | NM | NM | NM | NM | NM | NM | NS: CLA, CD11a, CCR4 |
10 | Herndler-Brandstetter et al. (30) | 2008 | CD8 | NR | NR | 1.1.1 Yes | Subsets | No | NM | NS | NM | NM | NM | NM | NM | NM | NM | NS : CD62L, CD11a, CD126, |
11 | Czesnikiewicz-Guzik et al. (31) | 2008 | CD4/CD8 | 41 | 68 | No | Total | No | ↓ | ↑ | NM | NM | NM | NM | NM | NM | NM | ↑ CD85j, ↓ CD26 |
12 | Nasi et al. (32) | 2006 | CD4/CD8 | 7 | 7 | No | Total | No | NM | NM | NM | NM | NM | NM | NM | NM | NM | NS : CD127 |
13 | Sawhney et al. (33) | 2006 | CD4/CD8 | 25 | 20 | No | Subsets | Yes | NM | NM | NM | ↑ | NM | NM | NM | NM | NM | CD4: ↑CD95L; CD8: NS CD95L |
14 | He et al. (35) | 2006 | CD8 | 15 | 22 | Yes | Subsets | No | ↓ | ↑ | NM | NM | NM | NM | NM | NM | NM | |
15 | Pinti et al. (36) | 2004 | CD4/CD8 | 14 | 13 | No | Subsets | No | NM | NM | NM | ↑ | NM | NM | NM | NM | NM | |
16 | Ouyang et al. (40) | 2003 | CD4/CD8 | 5 | 5 | Yes | Total | Yes | ↓ | NM | NM | NM | NM | NM | NM | NM | NM | NS: HLA-DR, CD69, CD45RO/RA |
17 | Machado et al. (41) | 2003 | CD4/CD8 | ± 10 | ± 20 | No | Total | No | NM | NM | NM | NM | NM | NM | NM | NM | NM | ↓ P-glycoprotein 1 |
18 | Ouyang et al. (42) | 2003 | CD8 | 70 | 11 | Yes | Total | Yes | NM | NM | ↑ | NM | NM | NM | NM | NM | NM | |
19 | Trzonkowski et al. (44) | 2003 | CD8 | 91 | 63 | Yes | Total | Yes | ↓ | ↑ | NM | NM | NM | NM | NM | NM | NM | |
20 | Trzonkowski et al. (47) | 2002 | CD8 | 65 | 31 | No | Total | No | ↓ | NM | NM | NM | NM | ↓ | NM | NM | NM | |
21 | Sandmand et al. (48) | 2002 | CD4/CD8 | 15 | 26 | No | Total | No | NM | NM | NM | ↑ | NM | NM | NM | NM | NM |
1. Information of Vδ1mean ± SD not reported ( Figures 1I , 3B ), 2. ( Figure 2A ). 3. Expression of the different markers among subpopulations of CD28/CD57, ( Figures 2 , 4 ). 4. The T cell subsets from old individuals express a greater array of senescent markers relative to young individuals ( Figure 1 ), 5. Dates shown in CD8 ( Figure 1D ), 6. Dates in Total CD8 T cell ( Figures 1A , 2A , 3B ), 7. Only in CD28− CD57+ cells a significantly higher p16 expression was found in the elderly compared to the Young subjects ( Figure 2B , 3 y 4), 8. ( Figure 3A ), 9. ( Figure S1 ), 10. CD8+CD45RO+CD25+ from elderly vs CD8+CD45RA+CD28+ from young ( Figure 1B ), 11. Dates in total CD8 T cells ( Figures 2A , 5A ), 12. ( Figure 5 . and text) 13. ( Figures 2 , 3 , 4 ), 14. CD57 increased and CD28 decreased in tetramer negative CD8 T cells, NS in tetramer-positive cells ( Figures 2B, C , 3B, C ), 15. No increase observed at single-cell level on CD45RA negative T lymphocytes ( Figure 4 ), 16. CMV peptide-specific CD8 ( Table 1 ), 17. ( Figures 1 , 2 ), 18. ( Figure 3B ), 19. Comparison between young responders and old ( Figure 1A ), 20. ( Table 1 ), 21. There was no difference between the two elderly groups (Centenarians >100 years, n=25), ( Table 1 ). The figures and tables correspond to the original article cited. ↑, increased in older; ↓, reduced in older; NS, no changes or not significant changes between the groups; NM, not measured; NC, not compared between the groups; NR, not reported.