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. 2021 Jan 15;11:604591. doi: 10.3389/fimmu.2020.604591

Table 2.

Characteristics of studies reporting immunosenescence markers.

No. References Year Lymphocyte definition Elderly Young CMV status Populations Stimulation Markers in elderly
n n CD28 CD57 KLRG1 CD95 PD1 CTLA4 TIM3 p16 p21 Others
1 Xu et al. (15) 2019 γ/δ 12 12 Yes Subsets No NM NM NM NM NM NM NM ↑CD85j, ↑CD244+, NC : γH2AX
2 Ross et al. (16) 2018 CD4/CD8 10 9 Yes Total No NM NM NM NM NM NM NM NM ↓CD31
3 Onyema et al. (19) 2015 CD8 11 11 No Subsets No NM NC NC NM NM NC ↑CD245, NC Bcl-2
4 Henson et al. (21) 2015 CD8 8 8 No Subsets Yes NM NM NM NM NM NM ↑ p38, ↑γH2AX
5 Canaday et al. 2013 CD4/CD8 24 24 No Total Yes NM NM NM NM NM NM ↓ ICOS in CD4 ex vivo
6 Dolfi et al. (25) 2013 CD8 ± 38 ± 37 No Total/subsets No NM NM NM NM NM NM ↑LAG-3 ↑2B4, ↑T-bet, ↑Eomes
7 Onyema O et al. (27) 2012 CD8 11 11 Yes Total/subsets No NM NM NM NM  
8 Libri et al. (28) 2011 CD4 25 Yes Subsets No NC NC NM NM NM NM NM NM NM IL-7Rα, Bcl-2
9 Agius et al. (29) 2009 CD4 ± 9 ± 11 No Total No NM NM NM NM NM NM NM NM NM NS: CLA, CD11a, CCR4
10 Herndler-Brandstetter et al. (30) 2008 CD8 NR NR 1.1.1 Yes Subsets No NM NS NM NM NM NM NM NM NM NS : CD62L, CD11a, CD126,
11 Czesnikiewicz-Guzik et al. (31) 2008 CD4/CD8 41 68 No Total No NM NM NM NM NM NM NM ↑ CD85j, ↓ CD26
12 Nasi et al. (32) 2006 CD4/CD8 7 7 No Total No NM NM NM NM NM NM NM NM NM NS : CD127 
13 Sawhney et al. (33) 2006 CD4/CD8 25 20 No Subsets Yes NM NM NM NM NM NM NM NM CD4: ↑CD95L; CD8: NS CD95L
14 He et al. (35) 2006 CD8 15 22 Yes Subsets No NM NM NM NM NM NM NM  
15 Pinti et al. (36) 2004 CD4/CD8 14 13 No Subsets No NM NM NM NM NM NM NM NM  
16 Ouyang et al. (40) 2003 CD4/CD8 5 5 Yes Total Yes NM NM NM NM NM NM NM NM NS: HLA-DR, CD69, CD45RO/RA
17 Machado et al. (41) 2003 CD4/CD8 ± 10 ± 20 No Total No NM NM NM NM NM NM NM NM NM ↓ P-glycoprotein 1
18 Ouyang et al. (42) 2003 CD8 70 11 Yes Total Yes NM NM NM NM NM NM NM NM  
19 Trzonkowski et al. (44) 2003 CD8 91 63 Yes Total Yes NM NM NM NM NM NM NM  
20 Trzonkowski et al. (47) 2002 CD8 65 31 No Total No NM NM NM NM NM NM NM
21 Sandmand et al. (48) 2002 CD4/CD8 15 26 No Total No NM NM NM NM NM NM NM NM  

1. Information of Vδ1mean ± SD not reported ( Figures 1I , 3B ), 2. ( Figure 2A ). 3. Expression of the different markers among subpopulations of CD28/CD57, ( Figures 2 , 4 ). 4. The T cell subsets from old individuals express a greater array of senescent markers relative to young individuals ( Figure 1 ), 5. Dates shown in CD8 ( Figure 1D ), 6. Dates in Total CD8 T cell ( Figures 1A , 2A , 3B ), 7. Only in CD28 CD57+ cells a significantly higher p16 expression was found in the elderly compared to the Young subjects ( Figure 2B , 3 y 4), 8. ( Figure 3A ), 9. ( Figure S1 ), 10. CD8+CD45RO+CD25+ from elderly vs CD8+CD45RA+CD28+ from young ( Figure 1B ), 11. Dates in total CD8 T cells ( Figures 2A , 5A ), 12. ( Figure 5 . and text) 13. ( Figures 2 , 3 , 4 ), 14. CD57 increased and CD28 decreased in tetramer negative CD8 T cells, NS in tetramer-positive cells ( Figures 2B, C , 3B, C ), 15. No increase observed at single-cell level on CD45RA negative T lymphocytes ( Figure 4 ), 16. CMV peptide-specific CD8 ( Table 1 ), 17. ( Figures 1 , 2 ), 18. ( Figure 3B ), 19. Comparison between young responders and old ( Figure 1A ), 20. ( Table 1 ), 21. There was no difference between the two elderly groups (Centenarians >100 years, n=25), ( Table 1 ). The figures and tables correspond to the original article cited. ↑, increased in older; ↓, reduced in older; NS, no changes or not significant changes between the groups; NM, not measured; NC, not compared between the groups; NR, not reported.