Table 2.
Mean and median changes in cytokine concentrations in the emixustat and placebo groups, in the study eye
| Cytokine concentration (pg/mL) | Emixustat group (N = 9)a | Placebo group (N = 11)b | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean baseline value (SD) | Mean day 85 value (SD) | Mean change (SD) | Median change (Q1, Q3) | Mean baseline value (SD) | Mean day 85 value (SD) | Mean change (SD) | Median change (Q1, Q3) | Difference in mean changes between groups | |
| IL-1βc | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | – |
| IL-6 | 7.3 (10.1) | 52.9 (141.3) | + 45.6 (137.1) | + 0.6 (0.0, + 10.0) | 6.5 (4.7) | 11.4 (12.0) | + 4.9 (12.6) | + 4.2 (− 5.1, + 9.6) | 0.34 |
| IL-8 | 11.3 (4.5) | 15.5 (5.4) | + 4.2 (5.1) | + 2.8 (+ 1.4, + 4.9) | 17.9 (19.8) | 20.4 (22.9) | + 2.6 (4.6) | + 2.8 (− 0.9, + 4.7) | 0.46 |
| TGFβ-1 | 69.3 (25.3) | 49.4 (31.3) | − 19.9 (32.4) | − 15.4 (− 30.8, 0.0) | 57.7 (32.8) | 40.2 (35.7) | − 17.5 (43.7) | − 22.6 (− 58.2, + 10.7) | 0.89 |
| VEGF | 509.6 (202.1) | 471.5 (181.0) | − 38.0 (115.1) | − 70.0 (− 84.9, + 23.9) | 714.4 (528.9) | 689.6 (339.8) | − 24.8 (277.2) | + 42.7 (− 102.9, + 74.6) | 0.90 |
aThe sample size was 9 in the emixustat group because 1 subject did not have a post-baseline aqueous humor sample taken, and 2 subjects discontinued the study early and were on the study drug for less than 60 days
bThe sample size was 11 in the placebo group because 1 subject did not have a post-baseline aqueous humor sample taken
cAll values were below the lower limit of detection and are recorded as zero