Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 19;259(2):413–424. doi: 10.1007/s00417-020-04930-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4. — Apical and basal cytokine secretions of RPE/choroid organ cultures after stimulation with TLR agonists. a IL-6 was constitutively secreted on the basal but not apical side in RPE/choroid organ cultures. Pam, Poly, and LPS induced the secretion on the apical and basal sides. Between the apical and basal sides, no significant differences could be found. b In untreated RPE/choroid organ culture, only minute amounts of IL-1ß could be found on the basal side. Pam, Poly I:C, and LPS significantly induced IL-1ß on both sides, however, to a much stronger degree on the basal side. The difference between the apical and basal sides are statistically significant. c Only small amounts of TNFα could be found on the basal side. Poly I:C and LPS significantly induced TNFα on both sides; however, the induction was much stronger on the basal side. Pam induced TNFα on the basal side only. The differences between basal and apical secretions are statistically significant (n = 6). Significance evaluated with the Kruskal–Wallis and Mann–Whitney U tests, ⁺p < 0.05, ⁺⁺p < 0.01, compared with control, and with the Wilcoxon matched-pairs signed rank test for comparison between apical and basal, *p < 0.05, **p < 0.01. Pam 100, Pam 100 ng/ml; Poly 100, Poly I:C 100 μg/ml; LPS 10, LPS 10 μg/ml