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. 2021 Jan 15;11:609856. doi: 10.3389/fmicb.2020.609856

TABLE 2.

Rapid identification of carbapenemases by NG-test Carba 5, RESIST-5 O.O.K.N.V., and IMP K-SeT.

Strains β -lactamase No. of positive tests/total no. of strains
Sensitivity [% (95% CI)] Specificity [% (95% CI)]
NG-test Carba 5 RESIST-5 O.O.K.N.V. IMP K-SeT
Clinical strains
KPC-2 70/70 70/70 0/70 100 (93.5–100) 100 (96.0–100)
NDM 60/60 100 (92.5–100) 100 (96.3–100)
59/60 0/60 98.3 (89.7–100) 100 (96.3–100)
NDM-1 35/35 34/35
NDM-5 23/23 23/23
NDM-7 1/1 1/1
NDM-9 1/1 1/1
IMP 6/6 0/6 6/6 100 (51.7–100) 100 (97.4–100)
IMP-4 5/5 0/5 5/5
IMP-6 1/1 0/1 1/1
OXA-48-like 24/24 24/24 0/24 100 (82.8–100) 100 (97.1–100)
OXA-232 20/20 20/20
OXA-48 2/2 2/2
OXA-181 2/2 2/2
VIM-1 1/1 1/1 0/1 100 (5.5–100) 100 (97.5–100)
Multiple carbapenemases 11/11 11/11 2/11 100 (67.9–100) 100 (97.3–100)
KPC-2 + NDM-1 7/7 7/7
KPC-2 NDM-5 1/1 1/1
NDM-5 OXA-48 1/1 1/1
NDM-1 IMP-4 1/1 1/1
NDM-1 IMP-6 1/1 1/1
Carbapenemase-negative 0/14 0/14 0/14
Total 172/186 100 (97.3–100) 100 (73.2–100)
165/186 6/186 99.4 (96.2–100) 100 (80.0–100)
Reference strains
KPC-2 14/14 14/14 0/14
NDM-1 6/6 6/6 0/6
IMP-1/70 1/1 0/1 1/1
VIM-1 2/2 2/2 0/2
OXA-48-like 3/3 3/3 0/3
OXA-48 2/2 2/2
OXA-181 1/1 1/1
ESBL 0/3 0/3 0/3
Total 26/29 100 (84.0–100) 100 (31.0–100)
25/29 1/1 100 (83.4–100) 100 (39.6–100)