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. 2021 Jan 15;8:556004. doi: 10.3389/fcell.2020.556004

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Copyright © 2021 Zhang, Pan and Shao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-202-3p inhibits the in vivo tumorigenicity of HCC cells by the KDM3A/HOXA1/MEIS3 pathway. (A) Tumor volume of HepG2 cells xenografted nude mice at indicated time points. (B) Representative mouse xenotransplanted tumors of HepG2 cells. (C) The scatter diagram of tumor weight of HepG2 cells xenografted nude mice. (D) The expression of miR-202-3p in tumor tissues collected from HepG2 cells xenografted nude mice was determined by qRT-PCR analysis. (E,F) Western blots and quantification of KDM3A, HOXA1, and MESI3 in tumor tissues collected from HepG2 cells xenografted nude mice. * (compared with control or agomir-NC + oe-NC) and # (compared with miR-202-3p agomir + oe-NC) indicate p < 0.05 by Tukey’s test-corrected one-way ANOVA for (C–F) and by Bonferroni-corrected repeated measures ANOVA for (A).