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miR-202-3p targets KDM3A, and the demethylase KDM3A binds to the promoter region of HOXA1, removes H3K9me2 modification, and enhances the expression of HOXA1; HOXA1 binds to the enhancer of MEIS3, enriches H3K4me1 and H3K27ac modification in the enhancer region, and activates the enhancer to promote the expression of MEIS3, thereby promoting the proliferation, migration, and invasion of HCC cells.
