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. 2020 Sep 7;36(2):242–251. doi: 10.1007/s00380-020-01688-9

Table 3.

Discrimination performance (ROC and AUC statistics) of severe AS entities in contrast to moderate AS

Parameters Entities AUC p value Lower 95% CI Upper 95% CI Threshold Sensitivity (%) Specificity (%) LR
Overall data
 AVC (AU) male HGAS 0.76 < 0.0001 0.69 0.83 > 2156 65 79 3.1
pLGAS 0.62 0.0081 0.53 0.71 > 1581 63 62 1.7
LGAS 0.61 0.0348 0.51 0.70 > 1589 53 62 1.4
 AVC (AU) female HGAS 0.85 < 0.0001 0.79 0.91 > 1540 62 93 9.0
pLGAS 0.66 0.0012 0.57 0.74 > 1016 50 73 1.8
LGAS 0.62 0.0425 0.51 0.74 > 1012 50 73 1.8
 AVC (AU/cm2) male HGAS 0.82 < 0.0001 0.76 0.89 > 406 75 75 3.0
pLGAS 0.63 0.0050 0.54 0.72 > 323 52 72 1.8
LGAS 0.62 0.0196 0.54 0.72 > 322 51 72 1.8
 AVC (AU/cm2) female HGAS 0.86 < 0.0001 0.81 0.92 > 259 80 80 3.9
pLGAS 0.66 0.0008 0.58 0.75 > 192 62 68 2.0
LGAS 0.63 0.00310 0.52 0.74 > 180 63 66 1.8
B) Adapted to LVF
 AVC (AU) male HGAS 0.76 < 0.0001 0.68 0.85 > 2156 76 72 2.8
pLGAS 0.54 0.4108 0.44 0.65 > 1754 55 56 1.2
LGAS 0.79 0.0002 0.67 0.90 > 1092 78 76 3.3
 AVC (AU) female HGAS 0.86 < 0.0001 0.80 0.93 > 1137 80 80 4.0
pLGAS 0.66 0.0022 0.57 0.75 > 848 58 63 1.6
LGAS 0.60 0.3580 0.40 0.79 > 1012 50 67 1.5
 AVC (AU/cm2) male HGAS 0.78 < 0.0001 0.70 0.86 > 506 59 78 2.7
pLGAS 0.54 0.4314 0.44 0.65 > 320 53 61 1.4
LGAS 0.81 < 0.0001 0.71 0.92 > 228 75 88 6.4
 AVC (AU/cm2) female HGAS 0.87 < 0.0001 0.81 0.93 > 275 80 83 4.6
pLGAS 0.67 0.0045 0.58 0.75 > 178 65 69 2.1
LGAS 0.63 0.2287 0.43 0.82 > 231 50 78 2.3
 NCC (AU) male HGAS 0.70 0.0003 0.60 0.80 > 1178 50 78 2.2
pLGAS 0.53 0.6028 0.42 0.63 > 656 55 56 1.2
LGAS 0.77 0.0004 0.65 0.89 > 370 80 76 3.4
 NCC (AU) female HGAS 0.81 < 0.0001 0.73 0.90 > 491 72 80 3.6
pLGAS 0.64 0.0074 0.54 0.74 > 277 63 63 1.7
LGAS 0.67 0.0985 0.48 0.87 > 286 65 78 2.9
 NCC (AU/cm2) male HGAS 0.70 0.0002 0.61 0.80 > 193 56 78 2.5
pLGAS 0.52 0.6549 0.42 0.63 > 114 60 50 1.2
LGAS 0.77 0.0004 0.65 0.90 > 63 79 76 3.3
 NCC (AU/cm2) female HGAS 0.83 < 0.0001 0.75 0.90 > 115 74 83 4.3
pLGAS 0.64 0.0075 0.42 0.63 > 74 60 69 1.9
LGAS 0.69 0.0660 0.49 0.90 > 70 63 78 2.8
 RCC (AU) male HGAS 0.76 < 0.0001 0.67 0.85 > 718 66 78 2.9
pLGAS 0.55 0.6228 0.45 0.66 > 415 60 58 1.5
LGAS 0.72 0.0054 0.58 0.85 > 157 89 50 1.8
 RCC (AU) female HGAS 0.82 < 0.0001 0.75 0.89 > 324 74 80 3.7
pLGAS 0.68 0.0010 0.58 0.77 > 192 71 60 1.8
LGAS 0.51 0.9042 0.28 0.75 < 249 54 67 1.6
 RCC (AU/cm2) male HGAS 0.77 < 0.0001 0.69 0.86 > 149 60 75 2.4
pLGAS 0.54 0.4473 0.43 0.65 > 76 63 61 1.6
LGAS 0.72 0.0054 0.58 0.85 > 42 81 59 2.0
pLGAS 0.67 0.0018 0.57 0.76 > 52 63 63 1.7
LGAS 0.53 0.7677 0.65 0.90 < 60 56 67 1.7
 LCC (AU) male HGAS 0.75 < 0.0001 0.66 0.85 > 427 81 67 2.4
pLGAS 0.57 0.2068 0.46 0.67 > 423 53 67 1.6
LGAS 0.73 0.0032 0.60 0.85 > 331 63 71 2.2
 LCC (AU) female HGAS 0.78 < 0.0001 0.70 0.86 > 319 64 83 3.8
pLGAS 0.60 0.0621 0.50 0.70 > 230 52 60 1.3
LGAS 0.52 0.8869 0.32 0.71 > 211 50 67 1.5
 LCC (AU/cm2) male HGAS 0.76 < 0.0001 0.67 0.85 > 98 75 69 2.5
pLGAS 0.57 0.2100 0.46 0.67 > 74 58 53 1.2
LGAS 0.75 0.0012 0.63 0.86 > 40 84 53 1.8
 LCC (AU/cm2) female HGAS 0.78 < 0.0001 0.70 0.86 > 67 73 77 3.2
pLGAS 0.60 0.0680 0.50 0.69 > 52 54 57 1.3
LGAS 0.54 0.7262 0.35 0.72 > 46 54 67 1.6

AVA aortic valve area, AVC aortic valve calcification, AU Agatston units, AUC area under the curve, LVOT left-ventricular outflow tract, NCC non-coronary cusp, RCC right coronary cusp

* p < 0.05